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Human PTGDS / L-PGDS Protein (His Tag)
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Human PTGDS / L-PGDS Protein (His Tag) PDF Download

Catalog   Size (Price) Quantity In Stock Operation
13346-H08H  
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Prostaglandin D2 synthase 21kDa (brain) Protein Datasheet

 

PTGDS / L-PGDS Protein Price Inquiry ( Available Sizes )

PTGDS / L-PGDS Protein Product Information

Synonym : PTGDS, PDS
Protein Construction:

A DNA sequence encoding the human PTGDS (P41222) (Met1-Gln190) was expressed with a polyhistidine tag at the C-terminus.

Source: Human
Expression Host: Human Cells

PTGDS / L-PGDS Protein QC Testing

Purity: > 80% as determined by SDS-PAGE SDS-PAGE:
SDS-PAGE

PTGDS / L-PGDS protein

Endotoxin: < 1.0 EU per μg of the protein as determined by the LAL method
Stability: Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N terminal: Ala 23
Molecular Mass:

The recombinant human PTGDS consists of  179 amino acids and predicts a molecular mass of 20.1 KDa. It migrates as an approximately 28 KDa band in SDS-PAGE under reducing conditions.

Formulation: Lyophilized from sterile PBS, pH 7.4.
  1. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
  2. Please contact us for any concerns or special requirements.

PTGDS / L-PGDS Protein Usage Guide

Storage: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

PTGDS / L-PGDS Protein Related Products & Topics

Related Areas:

Proteins:

Antibodies:

PTGDS / L-PGDS Protein Description

PTGDS, also known as L-PGDS, is a member of the calycin superfamily, lipocalin family. It is abundantly expressed in the heart, brain, and central nervous system(CNS), where it is expressed in tissues of the blood-brain barrier and secreted into the cerebro-spinal fluid. PTGDS is a glutathione-independent prostaglandin D synthase that catalyzes the conversion of PGH2 to PGD2. It is involved in a variety of CNS functions, such as sedation, NREM sleep and PGE2-induced allodynia, and may have an anti-apoptotic role in oligodendrocytes. It binds small non-substrate lipophilic molecules, including biliverdin, bilirubin, retinal, retinoic acid and thyroid hormone, and may act as a scavenger for harmful hydrophopic molecules and as a secretory retinoid and thyroid hormone transporter.

References

  1. Aebersold R. et al., 1993, Theor Electrophor. 3: 229-34.
  2. Oliver K. et al., 2004, Nature. 429: 369-74.
  3. Bonaldo MF. et al., 1997, Genome Res. 6 (9): 791-806.
 

 

PTGDS (L-PGDS) related areas, pathways, and other information

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"