|Catalog||Size (Price)||Quantity||In Stock||Operation||Other Information|
Prostaglandin D2 synthase 21kDa (brain) Protein Datasheet
PTGDS / L-PGDS Protein Price Inquiry ( Available Sizes )
PTGDS / L-PGDS Protein Product Information
|Synonym :||PTGDS, PDS|
A DNA sequence encoding the human PTGDS (P41222) (Met1-Gln190) was expressed with a polyhistidine tag at the C-terminus.
|Expression Host:||Human Cells|
PTGDS / L-PGDS Protein QC Testing
|Purity:||> 80% as determined by SDS-PAGE||SDS-PAGE:
PTGDS / L-PGDS protein
|Endotoxin:||< 1.0 EU per μg of the protein as determined by the LAL method|
|Stability:||Samples are stable for up to twelve months from date of receipt at -70℃|
|Predicted N terminal:||Ala 23|
The recombinant human PTGDS consists of 179 amino acids and predicts a molecular mass of 20.1 KDa. It migrates as an approximately 28 KDa band in SDS-PAGE under reducing conditions.
|Formulation:||Lyophilized from sterile PBS, pH 7.4.
PTGDS / L-PGDS Protein Usage Guide
|Storage:||Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.|
|Reconstitution:||A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.|
PTGDS / L-PGDS Protein Related Products & Topics
PTGDS / L-PGDS Protein Description
PTGDS, also known as L-PGDS, is a member of the calycin superfamily, lipocalin family. It is abundantly expressed in the heart, brain, and central nervous system(CNS), where it is expressed in tissues of the blood-brain barrier and secreted into the cerebro-spinal fluid. PTGDS is a glutathione-independent prostaglandin D synthase that catalyzes the conversion of PGH2 to PGD2. It is involved in a variety of CNS functions, such as sedation, NREM sleep and PGE2-induced allodynia, and may have an anti-apoptotic role in oligodendrocytes. It binds small non-substrate lipophilic molecules, including biliverdin, bilirubin, retinal, retinoic acid and thyroid hormone, and may act as a scavenger for harmful hydrophopic molecules and as a secretory retinoid and thyroid hormone transporter.
- Aebersold R. et al., 1993, Theor Electrophor. 3: 229-34.
- Oliver K. et al., 2004, Nature. 429: 369-74.
- Bonaldo MF. et al., 1997, Genome Res. 6 (9): 791-806.