All S6K1 reagents are produced in house and quality controlled, including 2 S6K1 Antibody, 29 S6K1 Gene, 1 S6K1 IPKit, 1 S6K1 Lysate, 1 S6K1 Protein, 1 S6K1 qPCR. All S6K1 reagents are ready to use.
Recombinant S6K1 proteins are expressed by Baculovirus-Insect Cells with fusion tags as N-GST.
S6K1antibodies are validated with different applications, which are WB, ICC/IF, IF, IP, ELISA.
S6K1cDNA clones are full length sequence confirmed and expression validated. There are 13 kinds of tags for each S6K1 of different species, especially GFP tag, OFP tag, FLAG tag and so on. There are three kinds of vectors for choice, cloning vector, expression vector and lentivrial expression vector.
PS6K, also known as RPS6KB1, is a serine/threonine-protein kinase. It belongs to the RSK (ribosomal s6 kinase) family. Members of this family function in signal transduction. PS6K is an isoform of p70 ribosomal S6 kinase (S6K). S6K can be activated by mitogenic stimuli such as growth factors, insulin and cytokines. It phosphorylates the ribosomal protein S6. PS6K also phosphorylates other proteins such as elF4B, eEF2K and SKAR. It is a crucial effector of mTOR(rapamycin) signaling. PS6K is dissociated from the EIF3 complex and activated upon mitogenic stimulation, phosphorylation by the mammalian target of mTOR complex 1 (mTORC1). Its active form then phosphorylates and activates several substrates in the preinitiation complex, including the EIF2B complex and the cap-binding complex component EIF4B. PS6K also functions in cell proliferation, cell growth and cell cycle progression.