>PROK1 / EG-VEGF Protein (His Tag)
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Prokineticin 1 Protein Datasheet
PROK1 / EG-VEGF Protein Price Inquiry ( Available Sizes )
PROK1 / EG-VEGF Protein Product Information
|Synonym :||EG-VEGF, PROK1|
A DNA sequence encoding the human EG-VEGF ( Met 1- Phe105) (P58294) was expressed, with a C-terminal polyhistidine tag.
|Expression Host:||Baculovirus-Insect cells|
PROK1 / EG-VEGF Protein QC Testing
|Purity:||> 89 % as determined by SDS-PAGE||SDS-PAGE:
PROK1 / EG-VEGF protein
|Endotoxin:||< 1.0 EU per μg of the protein as determined by the LAL method|
|Stability:||Samples are stable for up to twelve months from date of receipt at -70℃|
|Predicted N terminal:||Ala 20|
The secreted recombinant human EG-VEGF consists of 96 amino acids and predicts a molecular mass of 11 KDa. The apparent molecular mass of the protein is approximately 15 Kda in SDS-PAGE under reducing conditions due to glycosylation.
|Formulation:||Lyophilized from sterile 20mM Tris, 500mM NaCl, pH7.4, 0.02%Tween-80, 10% gly, 1mM DTT.
PROK1 / EG-VEGF Protein Usage Guide
|Storage:||Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.|
|Reconstitution:||A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.|
PROK1 / EG-VEGF Protein Related Products & Topics
PROK1 / EG-VEGF Protein Description
EG-VEGF belongs to the AVIT (prokineticin) family which is comprised by secreted proteins that can promote angiogenesis and induce strong gastrointestinal smooth muscle contraction. EG-VEGF positively regulates PTGS2 expression and prostaglandin synthesis. It may play a role in placentation. It may also functions in normal and pathological testis angiogenesis. EG-VEGF can be detected in the steroidogenic glands, ovary, testis, adrenal and placenta. It has little or no effect on a variety of other endothelial and non-endothelial cell types. It potently contracts gastrointestinal (GI) smooth muscle. It also induces proliferation, migration and fenestration (the formation of membrane discontinuities) in capillary endothelial cells derived from endocrine glands, but not migration, of enteric neural crest cells. EG-VEGF directly influences neuroblastoma progression by promoting the proliferation and migration of neuroblastoma cells.
- Masuda Y. et al., 2002, Biochem. Biophys. Res. Commun. 293 (1): 396-402.
- Pasquali D. et al., 2006, Endocrinology. 147 (9): 4245-51.
- Ngan ES. et al., 2008, Biochim Biophys Acta. 1783 (3): 467-78.
- Ngan ES. et al., 2007, Biochim Biophys Acta. 1773 (4): 536-45.