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>Human Cell Expressed
>Human Epcr / PROCR Protein (Fc Tag)
|Catalog||Size (Price)||Quantity||In Stock||Operation|
Protein C receptor, endothelial Protein Datasheet
PROCR / EPCR Protein Price Inquiry ( Available Sizes )
PROCR / EPCR Protein Product Information
|Synonym :||PROCR, EPCR|
A DNA sequence encoding the human PROCR (AAH14451.1) (Met1-Thr209) was expressed, fused with the Fc region of human IgG1 at the C-terminus.
|Expression Host:||Human Cells|
PROCR / EPCR Protein QC Testing
|Purity:||(20.4+75.1) % as determined by SDS-PAGE||SDS-PAGE:
PROCR / EPCR protein
|Endotoxin:||< 1.0 EU per μg of the protein as determined by the LAL method|
|Stability:||Samples are stable for up to twelve months from date of receipt at -70℃|
|Predicted N terminal:||Ser 18|
The recombinant human PROCR/Fc is a disulfide-linked homodimer. The reduced monomer comprises 433 amino acids and has a predicted molecular mass of 48.9 kDa. The apparent molecular mass of the protein is approximately 120 and 65 kDa in SDS-PAGE under reducing conditions.
|Formulation:||Lyophilized from sterile PBS, pH7.4.
PROCR / EPCR Protein Usage Guide
|Storage:||Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.|
|Reconstitution:||A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.|
PROCR / EPCR Protein Related Products & Topics
|Molecule||Species||Description //For Detailed Info. and Price------CLICK!||Cat. No|
|PROCR||Human||PROCR / EPCR Protein, Recombinant||13320-H02H|
|PROCR||Human||Epcr / PROCR Protein, Recombinant||13320-H08H|
|PROCR||Mouse||Epcr / PROCR Protein, Recombinant||50874-M02H|
|PROCR||Mouse||EPCR / PROCR Protein, Recombinant||50874-M08H|
|Molecule||Application||Description //For Detailed Info. and Price------CLICK!||Cat. No|
|Mouse PROCR||WB, ELISA||Epcr / PROCR Antibody||50874-RP01|
PROCR / EPCR Protein Description
Endothelial protein C receptor (EPCR), also known as activated protein C receptor (APC receptor) or PROCR, is a receptor for Protein C. Protein C plays an important role in many metabolism processes in humans and other animals after activated by binding to Endothelial protein C receptor (EPCR). Because of the EPCR is found primarily on endothelial cells(cells on the inside of blood vessels), activated protein C is found maily near endothelial cells. Protein C is pleiotropic, with two main functions: anticoagulation and cytoprotection. Which function will be performed depend on whether or not protein C remains bind to EPCR after activated. The anticoagulation occur when it does not. When still bound to EPCR, activated protein C performs its cytoprotective effects.
- Nicolaes GA. et al., 2003, Semin Vasc Med. 3 (1): 33-46.
- Esmon CT. 2003, Chest. 124 (3): 26-32.
- Mosnier LO. et al., 2007, Blood. 109: 3161-3172.