Anti-PRMT6 Antibody

Cat: 11313-RP01
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Anti-PRMT6 Antibody (Rabbit Polyclonal antibody) General Information
Product name
Anti-PRMT6 Antibody
Validated applications
ELISA
Species reactivity
Reacts with: Human
Specificity
Human PRMT6
Immunogen
Recombinant Human PRMT6 protein (Catalog#11313-H18H)
Preparation
Produced in rabbits immunized with purified, recombinant Human PRMT6 (rh PRMT6; Catalog#11313-H18H; NP_060607.2; Met 1-Asp 375). Total IgG was purified by Protein A affinity chromatography.
Source
Polyclonal Rabbit IgG
Purification
Protein A
Formulation
0.2 μm filtered solution in PBS with 5% trehalose
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-PRMT6 Antibody (Rabbit Polyclonal antibody) Validated Applications
Application Dilution Notes
ELISA 1:1000-1:2000  

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-PRMT6 Antibody Alternative Names
Anti-HRMT1L6 Antibody
PRMT6 Background Information

Protein arginine N-methyltransferase 6, also known as Histone-arginine N-methyltransferase PRMT6, PRMT6, and HRMT1L6, is a member of the protein arginine N-methyltransferase family and PRMT6 subfamily. PRMT6 is highly expressed in kidney and testes. PRMT6 is known to catalyze the generation of asymmetric dimethylarginine in polypeptides. It has been implicated in human immunodeficiency virus pathogenesis, DNA repair, and transcriptional regulation. PRMT6 is known to methylate histone H3 Arg-2 (H3R2), and this negatively regulates the lysine methylation of H3K4 resulting in gene repression. PRMT6 plays a key role in coupling process by functioning as a transcriptional coactivator that can regulate alternative splicing. PRMT6 coactivates the progesterone, glucocorticoid and oestrogen receptors in luciferase reporter assays in a hormone-dependent manner. Small interfering RNA (siRNA) oligonucleotide duplex knockdown of PRMT6 disrupts oestrogen-stimulated transcription of endogenous GREB1 and progesterone receptor in MCF-7 breast cancer cells. Neutralizing the activity of PRMT6 could inhibit tumor progression and may be of cancer therapeutic significance.

Full Name
protein arginine methyltransferase 6
References
  • Hyllus D, et al., 2007, Genes Dev. 21(24): 3369-80.
  • Lakowski, TM. et al., 2008, J Biol Chem. 283 (15): 10015-25. 
  • Michaud-Levesque, J. et al., 2009, J Biol Chem. 284 (32): 21338-46.
  • Harrison, MJ. et al., 2010, Nucleic acids Res. Jan 4.
  • Product Description Host Clonality Application Catalog# (PDF)
    Anti-PRMT6 Antibody Rabbit Polyclonal IHC-P,ICC/IF,IF 101041-T10
    Anti-PRMT6 Antibody Mouse Monoclonal WB,ELISA 11313-MM02
    Anti-PRMT6 Antibody Rabbit Polyclonal ICC/IF,IF 101041-T02
    Anti-PRMT6 Antibody Rabbit Polyclonal WB,IP 11313-RP02
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