PRMT3

PRMT3 methylates (mono and asymmetric dimethylation) the guanidino nitrogens of arginyl residues in some proteins.

PRMT3 Related Areas

Enzyme>>Methyltransferase>>PRMT3

PRMT3 Alternative Names

PRMT3, HRMT1L3 [Homo sapiens]

Prmt3, Hrmt1l3, 2010005E20Rik, 2410018A17Rik, AL033309 [Mus musculus]

Summaries for PRMT3

Entrez Gene summary for PRMT3:

Type I protein arginine N-methyltransferases (PRMTs), such as PRMT3, catalyze the formation of asymmetric N(G),N(G)-dimethylarginine (ADMA) residues in proteins (Tang et al., 1998 [PubMed 9642256]).[supplied by OMIM, Mar 2008]

OMIM - description for PRMT3:

Type I protein arginine N-methyltransferases (PRMTs), such as PRMT3, catalyze the formation of asymmetric N(G),N(G)-dimethylarginine (ADMA) residues in proteins (Tang et al., 1998).

Wikipedia summary for PRMT3:

Protein arginine N-methyltransferase 3 is an enzyme that in humans is encoded by the PRMT3 gene.

Human PRMT3 Protein General Information

 

• Protein names: PRMT3
• Sequence length: 531 AA.
• Domain: The zinc-finger is responsible for substrate specificity
• Sequence similarities: Belongs to the protein arginine N-methyltransferase family.
  Contains 1 C2H2-type zinc finger.
• Enzyme regulation: Inhibited by N-ethylmaleimide and high concentrations of zinc chloride.
• Subunit structure: May exist as a monomer or homodimer
• Subcellular location: Cytoplasm.

General information above from UniProt

Function for PRMT3 Protein

UniProtKB:

PRMT3 methylates (mono and asymmetric dimethylation) the guanidino nitrogens of arginyl residues in some proteins.

Genatlas:

• PRMT3 is ribosomal protein methyltransferase that affects the cellular level of ribosomal subunits
• PRMT3 regulates ribosome biosynthesis at a stage beyond pre-rRNA processing
• PRMT3 catalyses the formation of asymmetric dimethylarginine
• PRMT3 is implicated in ribosomal function and in the regulation of protein synthesis