Anti-RIZ1 Antibody

Cat: 11216-RP02
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All RIZ1 Reagents
Anti-RIZ1 Antibody (Rabbit Polyclonal antibody) General Information
Product name
Anti-RIZ1 Antibody
Validated applications
Species reactivity
Reacts with: Human
Human RIZ1
Recombinant Human PRDM2 protein (Catalog#11216-H09E)
Produced in rabbits immunized with purified, recombinant Human PRDM2 (rh PRDM2; Catalog#11216-H09E; NP_036363.2; Met 1-Ala 200). PRDM2 specific IgG was purified by human PRDM2 affinity chromatography .
Polyclonal Rabbit IgG
Protein A & Antigen Affinity
0.2 μm filtered solution in PBS with 5% trehalose
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-RIZ1 Antibody (Rabbit Polyclonal antibody) Validated Applications
Application Dilution Notes
ELISA 1:1000-1:2000  
IHC-P 1:500-1:2000  

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-RIZ1 Antibody (Rabbit Polyclonal antibody) Images
Human PRDM2/RIZ1 Immunohistochemistry(IHC) 3743
Immunochemical staining of human PRDM2 in human glioblastoma with rabbit polyclonal antibody (1:1000, formalin-fixed paraffin embedded sections). The left panel: tissue incubated with primary antibody; The right panel: tissue incubated with the mixture of primary antibody and antigen (recombinant protein).
Human PRDM2/RIZ1 Immunohistochemistry(IHC) 3744
Immunochemical staining of human PRDM2 in human astrocytoma with rabbit polyclonal antibody (1:1000, formalin-fixed paraffin embedded sections).
Anti-RIZ1 Antibody Alternative Names
Anti-HUMHOXY1 Antibody;Anti-KMT8 Antibody;Anti-MTB-ZF Antibody;Anti-RIZ Antibody;Anti-RIZ1 Antibody;Anti-RIZ2 Antibody
RIZ1 Background Information

PR domain containing 2, with ZNF domain (PRDM2), also known as zinc finger protein RIZ, is a member of histone methyltransferase (HMT) class enzymes that methylate lysine residues of histones or proteins. HMTs contain a conserved catalytic core termed the SET domain, which shares sequence homology with an independently described sequence motif, the PR domain. PRDM2 contains 8 C2H2-type zinc fingers and a distinct SET domain, and is highly expressed in retinoblastoma cell lines and in brain tumors, as well as in a number of other cell lines and in brain, heart, skeletal muscle, liver and spleen. PRDM2 is a S-adenosyl-L-methionine-dependent histone methyltransferase that specifically methylates 'Lys-9' of histone H3, and is identified as a tumor suppressor. It is reported that intact PR( SET) sequence is required for tumor suppression functions, mutations in the PR domain caused activity reduction in human cancers. Also, S-adenosylhomocysteine or methyl donor deficiency inhibits RIZ1 and other H3 lysine 9 methylation activities. PRDM2 may also function as a DNA-binding transcription factor. It Binds to the macrophage-specific TPA-responsive element (MTE) of the HMOX1 (heme oxygenase 1) gene and act as a transcriptional activator. In addition, PRDM2 (RIZ) is able to binds to the retinoblastoma protein (RB) and also Interacts with GATA3.

Full Name
PR domain containing 2, with ZNF domain
  • Buyes, I.M. et al., 1995, Proc. Natl. Acad. Sci. U.S.A. 92: 4467-4471.
  • Muraosa, Y. et al., 1996, Eur. J. Biochem. 235: 471-479.
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  • Shapiro, V.S. et al., 1995, Gene. 163: 329-330.
  • Briknarova, al.,2008,Biochem.Biophys.Res.Commun.366:807-813.
  • Product Description Host Clonality Application Catalog# (PDF)
    Anti-RIZ1 Antibody Rabbit Polyclonal ELISA 11216-RP01
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