All Calcineurin A reagents are produced in house and quality controlled, including 1 Calcineurin A Antibody, 29 Calcineurin A Gene, 1 Calcineurin A Lysate, 1 Calcineurin A Protein, 1 Calcineurin A qPCR. All Calcineurin A reagents are ready to use.
Recombinant Calcineurin A proteins are expressed by Baculovirus-Insect Cells with fusion tags as N-His.
Calcineurin Aantibodies are validated with different applications, which are IHC-P.
Calcineurin AcDNA clones are full length sequence confirmed and expression validated. There are 13 kinds of tags for each Calcineurin A of different species, especially GFP tag, OFP tag, FLAG tag and so on. There are three kinds of vectors for choice, cloning vector, expression vector and lentivrial expression vector.
Expression host: Baculovirus-Insect Cells
PPP3CA, also known as protein phosphatase 2B, is a member of the PPP phosphatase family, PP-2B subfamily. It is the alpha catalytic subunit of protein phosphatase 2B (PP2B). PP2B is a holoenzyme that is comprised of a catalytic subunit associated with regulatory subunits. It is a calcium regulated enzyme that is activated by calmodulin and participates in the signaling cascades involved in development of the nervous, cardiovascular, and musculoskeletal systems. PPP3CA activates the T cells of the immune system and can be blocked by drugs. It also activates NFATc (a transcription factor) by dephosphorylating it. The activated NFATc is subsequently translocated into the nucleus, where it upregulates the expression of interleukin 2. PPP3CA interacts with CRTC2, MYOZ1, MYOZ2 and MYOZ3. It also interacts with DNM1L. The interaction dephosphorylates DNM1L and regulates its translocation to mitochondria.