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PPP2CB  Protein, Antibody, ELISA Kit, cDNA Clone

PPP2CB Related Pathways

    PPP2CB Related Protein, Antibody, cDNA Gene, and ELISA Kits

    PPP2CB Related Protein, Antibody, cDNA Gene, and ELISA Kits

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    PPP2CB Summary & Protein Information

    PPP2CB Background

    Catalytic activity: A phosphoprotein + H(2)O = a protein + phosphate.
    Cofactor: Binds 1 iron ion per subunit (By similarity).
    Binds 1 manganese ion per subunit (By similarity).
    Subunit structure: Found in a complex with at least ARL2, PPP2CB, PPP2R1A, PPP2R2A, PPP2R5E and TBCD. Interacts with TBCD (By similarity). PP2A consists of a common heterodimeric core enzyme (composed of a 36 kDa catalytic subunit (subunit C) and a 65 kDa constant regulatory subunit (PR65) (subunit A)) that associates with a variety of regulatory subunits. Proteins that associate with the core dimer include three families of regulatory subunits B (the R2/B/PR55/B55, R3/B''/PR72/PR130/PR59 and R5/B'/B56 families), the 48 kDa variable regulatory subunit, viral proteins, and cell signaling molecules. Binds PPME1. May indirectly interact with SGOL1, most probably through regulatory B56 subunits. Interacts with CTTNBP2NL.
    Subcellular location: Cytoplasm. Nucleus. Chromosome, centromere. Cytoplasm, cytoskeleton, spindle pole. Note=In prometaphase cells, but not in anaphase cells, localizes at centromeres. During mitosis, also found at spindle poles.
    Post-translational: Reversibly methyl esterified on Leu-309. Carboxyl methylation may play a role in holoenzyme assembly. It varies during the cell cycle. Demethylated by PME1 (in vitro).
    Phosphorylation of either threonine (by autophosphorylation- activated protein kinase) or tyrosine results in inactivation of the phosphatase. Auto-dephosphorylation has been suggested as a mechanism for reactivation.
    Sequence similarity: Belongs to the PPP phosphatase family. PP-1 subfamily.C
    General information above from UniProt

    PPP2CB Alternative Name

    PP2CB,PP2Abeta, [homo-sapiens]
    PP2Ac,AI115466,D8Ertd766e, [mus-musculus]

    PPP2CB Related Studies

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