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PPM1G Protein, Antibody, ELISA Kit, cDNA Clone

PPM1G Related Areas

PPM1G Related Pathways

PPM1G Related Product

    PPM1G Summary & Protein Information

    PPM1G Background

    Gene Summary: The protein encoded by PPM1G gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase is found to be responsible for the dephosphorylation of Pre-mRNA splicing factors, which is important for the formation of functional spliceosome. Studies of a similar gene in mice suggested a role of this phosphatase in regulating cell cycle progression. [provided by RefSeq, Apr 2010]
    General information above from NCBI
    Catalytic activity: A phosphoprotein + H(2)O = a protein + phosphate.
    Cofactor: Binds 2 magnesium or manganese ions per subunit (By similarity).
    Subcellular location: Cytoplasm (Potential).
    Tissue specificity: Widely expressed. Most abundant in testis, skeletal muscle, and heart.
    Sequence similarity: Belongs to the PP2C family.C
    General information above from UniProt

    Protein phosphatase 1G, also known as Protein phosphatase 1C, Protein phosphatase 2C isoform gamma, Protein phosphatase magnesium-dependent 1 gamma, PP2C-gamma, PPM1G and PPM1C, is a cytoplasm protein which belongs to the PP2C family. PPM1G / PP2C-gamma is widely expressed. It is most abundant in testis, skeletal muscle, and heart. Alternatively spliced transcript variants encoding the same protein have been described. PP2C family members are known to be negative regulators of cell stress response pathways.  PPM1G / PP2C-gamma is found to be responsible for the dephosphorylation of Pre-mRNA splicing factors, which is important for the formation of functional spliceosome. PPM1G / PP2C-gamma also plays a role in regulating cell cycle progression.

    PPM1G Alternative Name

    MGC1675,MGC2870,PP2CG,PP2CGAMMA,PPM1G,PPP2CG, [human]
    AI385652,Fin13,Ppm1g, [mouse]

    PPM1G Related Studies

  • Travis S.M., et al., 1997, FEBS Lett. 412:415-9.
  • Molina H., et al., 2007, Proc. Natl. Acad. Sci. USA. 104: 2199-204.
  • Matsuoka S., et al., 2007, Science 316:1160-6.
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