PPM1A / PP2CA Protein & Antibody

Protein Phosphatase, Mg²⁺/Mn²⁺ dependent, 1A / Phosphatase 2C alpha

PPM1A / PP2CA Products

PPM1A / PP2CA Protein, Recombinant

Molecule	Species	Description	Cat. No
PPM1A/PP2CA	Mouse	PPM1A/PP2CA Protein, Recombinant	50277-M08E
PPM1A/PP2CA	Human	PPM1A / PP2C-alpha Protein, Recombinant	12984-H08E

PPM1A / PP2CA Antibody

Molecule	Application	Description	Cat. No
Mouse PPM1A/PP2CA	WB, ELISA	PPM1A/PP2CA Antibody, Rabbit PAb	50277-RP01
Mouse PPM1A/PP2CA	WB, ELISA	PPM1A/PP2CA Antibody, Rabbit PAb (Antigen Affinity Purified)	50277-RP02

PPM1A / PP2CA cDNA Clone

Molecule	Species	Description	Cat. No
PPM1A/PP2CA	Mouse	Mus musculus PPM1A/PP2CA cDNA Clone	MG50277-M

PPM1A / PP2CA Related Areas

Enzyme>>Phosphatase & Regulator>>PPM1A/PP2CA

Signal Transduction>>Phosphatase & Regulator>>PPM1A/PP2CA

PPM1A / PP2CA Alternative Names

PPM1A , PP2CA, PP2C-ALPHA, PP2Calpha, FLJ42306, MGC9201 [Homo sapiens]

Ppm1a, PP2CA, PP2C-alpha, 2310003C21Rik, 2900017D14Rik, AI427932, AU017636, MMPa-2, MPPa-1 [Mus musculus]

PPM1A / PP2CA Background

Protein phosphatase 1A (PPM1A / PP2CA) is an enzyme belonging to the PP2C family of Ser / Thr protein phosphatases. Members of PP2C family are negative regulators of cell stress response pathways and the MAP kinases and MAP kinase kinases. It has also been demonstrated to inhibit the activation of p38 and JNK kinase cascades. PPM1A dephosphorylates and promotes nuclear export of TGFβ-activated Smad2/3. Ectopic expression of PPM1A abolishes TGFβ-induced antiproliferative and transcriptional responses, whereas depletion of PPM1A enhances TGFβ signaling in mammalian cells. It has been demonstrated that PPM1A / PP2CA, through dephosphorylation of Smad2/3, plays a critical role in terminating TGFβ signaling. Overexpression of PPM1A is reported to activate the expression of the tumor suppressor gene TP53 / p53, which leads to cell apoptosis.

PPM1A / PP2CA Related Studies

1. Lin X, et al. (2006) PPM1A functions as a Smad phosphatase to terminate TGFbeta signaling. Cell. 125(5): 915-28.
2. Marc F, et al. (2003) Protein phosphatase 2C binds selectively to and dephosphorylates metabotropic glutamate receptor 3. Proc Natl Acad. 100 (26): 16006–11.
3. Mann DJ, et al. (1992) Mammalian protein serine/threonine phosphatase 2C: cDNA cloning and comparative analysis of amino acid sequences. Biochim Biophys Acta. 1130 (1): 100–4.