Anti-PPM1A Antibody

Cat: 50277-RP01
Contact us:
215-583-7898
order@sinobiological.com
Distributors
All PPM1A Reagents
CRO Services
Product recommended

All PPM1A Reagents
Anti-PPM1A Antibody (Rabbit Polyclonal antibody) General Information
Product name
Anti-PPM1A Antibody
Validated applications
ELISA
Species reactivity
Reacts with: Mouse
Specificity
Mouse PPM1A
Immunogen
Recombinant Mouse PPM1A protein (Catalog#50277-M08E)
Preparation
Produced in rabbits immunized with purified, recombinant Mouse PPM1A (rM PPM1A; Catalog#50277-M08E; NP_032936.1; Met 1-Trp 382). Total IgG was purified by Protein A affinity chromatography .
Source
Polyclonal Rabbit IgG
Purification
Protein A
Formulation
0.2 μm filtered solution in PBS with 5% trehalose
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-PPM1A Antibody (Rabbit Polyclonal antibody) Validated Applications
Application Dilution Notes
ELISA 1:1000-1:2000  

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-PPM1A Antibody Alternative Names
Anti-2310003C21Rik Antibody;Anti-2900017D14Rik Antibody;Anti-AI427932 Antibody;Anti-AU017636 Antibody;Anti-MMPa-2 Antibody;Anti-MPPa-1 Antibody
PPM1A Background Information

Protein phosphatase 1A (PPM1A / PP2CA) is an enzyme belonging to the PP2C family of Ser / Thr protein phosphatases. Members of PP2C family are negative regulators of cell stress response pathways and the MAP kinases and MAP kinase kinases. It has also been demonstrated to inhibit the activation of p38 and JNK kinase cascades. PPM1A dephosphorylates and promotes nuclear export of TGFβ-activated Smad2/3. Ectopic expression of PPM1A abolishes TGFβ-induced antiproliferative and transcriptional responses, whereas depletion of PPM1A enhances TGFβ signaling in mammalian cells. It has been demonstrated that PPM1A / PP2CA, through dephosphorylation of Smad2/3, plays a critical role in terminating TGFβ signaling. Overexpression of PPM1A is reported to activate the expression of the tumor suppressor gene TP53 / p53, which leads to cell apoptosis.

Full Name
protein phosphatase, Mg2+/Mn2+ dependent, 1A
References
  • Lin X, et al. (2006) PPM1A functions as a Smad phosphatase to terminate TGFbeta signaling. Cell. 125(5): 915-28.
  • Marc F, et al. (2003) Protein phosphatase 2C binds selectively to and dephosphorylates metabotropic glutamate receptor 3. Proc Natl Acad. 100 (26): 16006-11.
  • Mann DJ, et al. (1992) Mammalian protein serine/threonine phosphatase 2C: cDNA cloning and comparative analysis of amino acid sequences. Biochim Biophys Acta. 1130 (1): 100-4.
  • Product Description Host Clonality Application Catalog# (PDF)
    Anti-PPM1A Antibody Rabbit Polyclonal WB,ELISA,IP 50277-RP02
    Anti-PPM1A Antibody Rabbit Monoclonal WB 50277-R006
    Anti-PPM1A Antibody (FITC) Mouse Monoclonal FCM 12984-MM01-F
    Anti-PPM1A Antibody Rabbit Polyclonal WB,ELISA,ICC/IF,IF 12984-T50
    Anti-PPM1A Antibody (PE) Mouse Monoclonal FCM 12984-MM01-P
    Anti-PPM1A Antibody Mouse Monoclonal FCM,ICC/IF,IF 12984-MM01
    Anti-PPM1A Antibody Mouse Monoclonal ELISA 12984-MM07
    info info
    添加购物车成功! 添加购物车失败!