- EGFR Signaling Pathway
- TGF-beta Signaling
- Canonical Wnt Signaling
- non-Canonical Wnt Signaling
- Notch Signaling
- p53 Pathway
- NF-kB Pathway
- Cytokine Signaling
|Catalog||Size (Price)||Quantity||In Stock||Operation|
FK506 binding protein 7 Protein Datasheet
PPIase / FKBP7 Protein Price Inquiry ( Available Sizes )
PPIase / FKBP7 Protein Product Information
A DNA sequence encoding the human FKBP7 (Q9Y680-2) (Met1-Gln218) was expressed with a polyhistidine tag at the C-terminus.
|Expression Host:||Human Cells|
PPIase / FKBP7 Protein QC Testing
|Purity:||(84.2+12.5)% as determined by SDS-PAGE||SDS-PAGE:
PPIase / FKBP7 protein
|Endotoxin:||< 1.0 EU per μg of the protein as determined by the LAL method|
|Stability:||Samples are stable for up to twelve months from date of receipt at -70℃|
|Predicted N terminal:||Gln 24|
The recombinant human FKBP7 consists of 206 amino acids and predicts a molecular mass of 23.8 KDa. It migrates as an approximately 27and 30 KDa band in SDS-PAGE under reducing conditions.
|Formulation:||Lyophilized from sterile PBS, pH 7.4.
PPIase / FKBP7 Protein Usage Guide
|Storage:||Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.|
|Reconstitution:||A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.|
PPIase / FKBP7 Protein Related Products & Topics
|Molecule||Species||Description //For Detailed Info. and Price------CLICK!||Cat No|
|PPIase||Human||PPIase / FKBP7 Protein, Recombinant||13250-H02H|
|PPIase||Human||PPIase / FKBP7 Protein, Recombinant||13250-H08H|
PPIase / FKBP7 Protein Description
PPIases contains 1 PPIase cyclophilin-type domain and belongs to the cyclophilin-type PPIase family, PPIL3 subfamily. It also is a member of the immunophilin protein family. Members of this family play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. PPIases catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerate the folding of proteins. It also may be involved in pre-mRNA splicing.PPIases has a very high substrate specificity for the four-residue peptide Ala-Ala-Pro-Phe only when the proline peptide bond is in the trans state. It is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 and rapamycin. It interacts with several intracellular signal transduction proteins including type I TGF-beta receptor. It also interacts with multiple intracellular calcium release channels, and coordinates multi-protein complex formation of the tetrameric skeletal muscle ryanodine receptor.
- Shor B. et al., 2008, Cancer Res. 68 (8): 2934-43.
- Talmud PJ. et al., 2009, Am J Hum Genet. 85 (5): 628-42.
- Deleersnijder A. et al., 2011, J Biol Chem. 286 (30): 26687-701.