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Cynomolgus monkey PPBP Gene cDNA Clone (full-length ORF Clone)

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CXCL7/PpbpcDNA Clone Product Information
Gene Bank Ref.ID:unsubmitted
cDNA Size:387
cDNA Description:ORF Clone of Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) pro-platelet basic protein (chemokine (C-X-C motif) ligand 7) DNA.
Gene Synonym:PPBP
Species:Cynomolgus
Vector:pGEM-T Vector
Restriction Site:
Tag Sequence:
Sequence Description:Identical with XM_001089019.2 [ Macaca mulatta (Rhesus monkey) ] sequence. Please check the sequence information before order.
Shipping Carrier:Each tube contains approximately 10 μg of lyophilized plasmid.
Storage:The lyophilized plasmid can be stored at ambient temperature for three months.
pGEM-T Vector Information

The pGEM-T is 3kb in length, and contains the amplicin resistance gene, conferring selection of the plasmid in E. coli, and the ori site which is the bacterial origin of replication. The plasmid has multiple cloning sites as shown below. The coding sequence was inserted by TA cloning. Many E. coli strains are suitable for the propagation of this vector including JM109, DH5α and TOP10.

pGEM-T Simple Usage Suggestion:

The coding sequence can be easily obtained by digesting the vector with proper restriction enzyme(s). The coding sequence can also be amplified by PCR with M13 primers, or primer pair SP6 and T7.

Vector Sequence Download
Chemokine & Receptor Related Products
Product nameProduct name
Human CXCL2 / MIP-2 ProteinRat CXCL1 / MGSA / NAP-3 ProteinRat CXCL2 / MIP-2 ProteinHuman CCL2 / MCP-1 / MCP1 Protein (His Tag)Mouse NAP-2 / PPBP / CXCL7 Protein (aa 49-109, His Tag)Mouse NAP-2 / PPBP / CXCL7 Protein (aa 40-113, His Tag)Mouse CCL22 / MDC Protein (His Tag)Mouse CXCL14 / BRAK ProteinMouse CXCL1 / MGSA / NAP-3 ProteinHuman NAP-2 / PPBP / CXCL7 Protein (His Tag)Human IL-8 / CXCL8 Protein (aa 28-99)Human CCL13 / MCP-4 Protein (His Tag)Human CCL18 / PARC / MIP4 Protein (His Tag)Mouse CCL2 / MCP-1 / MCP1 Protein (His Tag)Human CCL16 / HCC-4 / NCC4 Protein (His Tag)Human CCL16 / HCC-4 / NCC4 Protein (His Tag)Human CCL4 / MIP1B Protein (His Tag)Human CCL3 / Mip1a Protein (His Tag)Human I-309 / CCL1 / TCA-3 Protein (Fc Tag)Human Fractalkine / CX3CL1 Protein (His Tag)Human CXCL12 / SDF1b Protein (Fc Tag)Human CXCL4 / PF4 ProteinHuman IL-8 / CXCL8 Protein (aa 23-99, Fc Tag)Human IL-8 / CXCL8 Protein (aa 23-99)Human IL-8 / CXCL8 Protein (aa 28-99, Fc Tag)Human IL-8 / CXCL8 Protein (aa 28-99)Human CXCL3 / GRO gamma Protein (His Tag)Human CCL5 / RANTES Protein (His & mucin Tag)Mouse CXCL16 / SR-PSOX Protein (His Tag)Human MCP-3 / CCL7 Protein (His Tag)Human CCL8 / MCP-2 Protein (SUMO Tag)Human CXCL1 / MGSA / NAP-3 Protein (His & SUMO Tag)Human CCL17 / TARC / SCYA17 Protein (His Tag)Mouse CXCL2 / GRO2 / MIP-2 (His & SUMO Tag)Human CCL15 / MIP-5 / MIP-1 delta Protein (aa 22-113, His Tag)Human CCL17 / TARC / SCYA17 ProteinMouse CCL8 / MCP-2 Protein (His & NusA Tag)Mouse CCL6 / C-C motif ligand 6 Protein (His Tag)Cynomolgus CXCL13 / BCA-1 / BLC Protein (His Tag)Human CXCL1 / MGSA / NAP-3 Protein (His & NusA Tag)Cynomolgus CXCL12 / SDF-1 Protein (Fc Tag)Mouse CXCL9 / MIG / C-X-C motif chemokine 9 ProteinHuman CXCL9 / MIG / C-X-C motif chemokine 9 ProteinHuman CCL21 / 6Ckine ProteinHuman CCL14 / HCC-1 / HCC-3 Protein (His Tag)Mouse CCL17 / TARC ProteinCynomolgus / Rhesus Fractalkine / CX3CL1 Protein (Fc Tag)Human CCL14 / HCC-1 / HCC-3 Protein (aa 28-93, His Tag)Human MCP-3 / CCL7 Protein (His Tag)Mouse I-309 / CCL1 / TCA-3 Protein (Fc Tag)Human CCL11 Protein (His Tag)Human CXCL12 / SDF-1 ProteinMouse XCL1 Protein (His Tag)Rat NAP-2 / PPBP / CXCL7 Protein (Fc Tag)Human XCL1 Protein (His Tag)Human CCL15 / MIP-5 / MIP-1 delta Protein (aa 46-113, His Tag)Human XCL2 Protein (His Tag)Human CXCL12 / SDF-1 Protein (isoform a, His Tag)Rat CXCL16 / SR-PSOX Protein (His Tag)Cynomolgus XCL1 Protein (His Tag)Human CCL22 / MDC Protein (His Tag)Mouse CCL20 / MIP-3 alpha Protein (His Tag)Human CCL24 / Eotaxin-2 / MPIF-2 Protein (His Tag)Human CXCL12 / SDF-1 Protein (isoform a)Cynomolgus CCL21 / 6Ckine ProteinHuman CXCL1 / MGSA / NAP-3 ProteinHuman FAM19A2 Protein (Fc Tag)Human CXCL10 / Crg-2 ProteinCanine IL-8 / CXCL8 ProteinRat CXCL16 / SR-PSOX Protein (Fc Tag)Cynomolgus NAP-2 / PPBP / CXCL7 Protein (Fc Tag)Human CXCL5 ProteinHuman I-309 / CCL1 / TCA-3 ProteinMouse CCL3 / Mip1a ProteinCynomolgus CCL17 / TARC Protein (His Tag)Mouse CXCL12 / SDF-1 ProteinCynomolgus CXCL9 / MIG / C-X-C motif chemokine 9 ProteinCynomolgus IL-8 / CXCL8 ProteinCanine CXCL12 / SDF-1 ProteinCanine CXCL13 / BCA-1 Protein (His Tag)Human CCL28 Protein (His Tag)Canine CXCL16 / SR-PSOX Protein (His Tag)Human CCL27 / CTACK Protein (His Tag)Human CXCL14 / BRAK ProteinHuman CCL23 / MIP 3 Protein (His Tag)Human CCL23 / MIP 3 ProteinCanine CXCL16 / SR-PSOX Protein (Fc Tag)Canine Fractalkine / CX3CL1 Protein (Fc Tag)Canine Fractalkine / CX3CL1 ProteinCanine XCL1 Protein (His Tag)Human CCL20 / MIP-3 alpha Protein (His Tag)Rat CCL3 / Mip1a ProteinHuman FAM19A4 / TAFA4 Protein (Fc Tag)Mouse MCP-3 / CCL7 Protein (His Tag)Human CCL5 / RANTES Protein
Background

Pro-platelet basic protein (PPBP) is also known as Chemokine (C-X-C motif) ligand 7 (CXCL7) and nucleosome assembly protein (Nap-2). Nap-2 / PPBP / CXCL7 is released in large amounts from platelets following their activation and is a platelet-derived growth factor that belongs to the CXC chemokine family. This growth factor is a potent chemoattractant and activator of neutrophils. Nap-2 / PPBP / CXCL7 has been shown to stimulate various cellular processes including DNA synthesis, mitosis, glycolysis, intracellular cAMP accumulation, prostaglandin E2 secretion, and synthesis of hyaluronic acid and sulfated glycosaminoglycan. It also stimulates the formation and secretion of plasminogen activator by synovial cells. Nap-2 is a ligand for CXCR1 and CXCR2, and Nap-2, Nap-2 (73), Nap-2 (74), Nap-2 (1-66), and most potent Nap-2 (1-63) are chemoattractants and activators for neutrophils.

References
  • Walz A, et al. (1989) Effects of the neutrophil-activating peptide NAP-2, platelet basic protein, connective tissue-activating peptide III and platelet factor 4 on human neutrophils. J Exp Med. 170(5):1745-50.
  • Walz A, et al. (1990) Generation of the neutrophil-activating peptide NAP-2 from platelet basic protein or connective tissue-activating peptide III through monocyte proteases. J Exp Med. 171(2): 449-54.
  • Loetscher P, et al. (1994) Both interleukin-8 receptors independently mediate chemotaxis. Jurkat cells transfected with IL-8R1 or IL-8R2 migrate in response to IL-8, GRO alpha and NAP-2. FEBS Lett. 341(2-3): 187-92.
  • Catalog:CG90132-G
    List Price: $95.00  (Save $0.00)
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