This PNLIP gene is a member of the lipase gene family. It encodes a carboxyl esterase that hydrolyzes insoluble, emulsified triglycerides, and is essential for the efficient digestion of dietary fats. This PNLIP gene is expressed specifically in the pancreas. [provided by RefSeq, Jul 2008]
OMIM-Description for PNLIPN
Pancreatic lipase (EC 126.96.36.199), a 56-kD protein that hydrolyzes dietary long chain triglycerides to free fatty acids and monoacylglycerols, is essential for the intestinal absorption of fats. The activity of pancreatic lipase (PNLIP)is stimulated in the presence of intestinal bile salts by pancreatic colipase (120105) (summary by Lowe et al., 1989).
Pancreatic lipase, also known as pancreatic triacylglycerol lipase (PNLIP), is secreted from thepancreas, and is the primary lipase (enzyme) that hydrolyzes (breaks down) dietary fat moleculesin the human digestive system, converting triglyceride substrates found in ingested oils tomonoglycerides and free fatty acids. Triacylglycerol + 2 H2O 2-monoacylglycerol + 2 fatty acid anions Bile salts secreted from the liver and stored in gallbladder are released into the duodenum where they coat and emulsify large fat droplets into smaller droplets, thus increasing the overall surface area of the fat, which allows the lipase to break apart the fat more effectively. The resultingmonomers (2 free fatty acids and one 2-monoacylglycerol) are then moved by way of peristalsisalong the small intestine to be absorbed into the lymphatic system by a specialized vessel called a lacteal. This PNLIP protein belongs to pancreatic lipase family. PNLIP is unlike some pancreatic enzymes that are activated by proteolytic cleavage (e.g. trypsinogen), pancreatic lipase is secreted in its final form. However it only becomes efficient in the presence ofcolipase in the duodenum. In humans, pancreatic lipase is encoded by the PNLIP gene.