PNLIP

PNLIP is an enzyme which belongs to the lipase family. Secreted from the pancreas, PNLIP is the primary lipase that hydrolyzes dietary fat molecules in the human digestive system, converting triglyceride substrates found in ingested oils to monoglycerides and free fatty acids. Bile salts secreted from the liver and stored in gallbladder are released into the duodenum where they coat and emulsify large fat droplets into smaller droplets, thus increasing the overall surface area of the fat, which allows the lipase to break apart the fat more effectively. The resulting monomers (2 free fatty acids and one 2-monoacylglycerol) are then moved by way of peristalsis along the small intestine to be absorbed into the lymphatic system by a specialized vessel called a lacteal.

PNLIP Related Areas

 

PNLIP Alternative Names

RP11-33D13.1, PL, PNLIPD, PTL, pancreatic triacylglycerol lipase, triacylglycerol acylhydrolase [Homo sapiens]

1810007A24Rik, PL, PTL, pancreatic triacylglycerol lipase, pancreatic triglyceride lipase [Mus musculus]

Summaries for PNLIP

Entrez Gene summary for PNLIP:

This PNLIP gene is a member of the lipase gene family. It encodes a carboxyl esterase that hydrolyzes insoluble, emulsified triglycerides, and is essential for the efficient digestion of dietary fats. This PNLIP gene is expressed specifically in the pancreas. [provided by RefSeq, Jul 2008]

OMIM - description for PNLIP:

Pancreatic lipase (EC 3.1.1.3), a 56-kD protein that hydrolyzes dietary long chain triglycerides to free fatty acids and monoacylglycerols, is essential for the intestinal absorption of fats. The activity of pancreatic lipase (PNLIP)is stimulated in the presence of intestinal bile salts by pancreatic colipase (120105) (summary by Lowe et al., 1989).

Wikipedia summary for PNLIP:

Pancreatic lipase, also known as pancreatic triacylglycerol lipase (PNLIP), is secreted from thepancreas, and is the primary lipase (enzyme) that hydrolyzes (breaks down) dietary fat moleculesin the human digestive system, converting triglyceride substrates found in ingested oils tomonoglycerides and free fatty acids.
Triacylglycerol + 2 H2O 2-monoacylglycerol + 2 fatty acid anions
Bile salts secreted from the liver and stored in gallbladder are released into the duodenum where they coat and emulsify large fat droplets into smaller droplets, thus increasing the overall surface area of the fat, which allows the lipase to break apart the fat more effectively. The resultingmonomers (2 free fatty acids and one 2-monoacylglycerol) are then moved by way of peristalsisalong the small intestine to be absorbed into the lymphatic system by a specialized vessel called a lacteal. This PNLIP protein belongs to pancreatic lipase family.
PNLIP is unlike some pancreatic enzymes that are activated by proteolytic cleavage (e.g. trypsinogen), pancreatic lipase is secreted in its final form. However it only becomes efficient in the presence ofcolipase in the duodenum.
In humans, pancreatic lipase is encoded by the PNLIP gene.

Human PNLIP Protein General Information

 

• Protein names: Pancreatic triacylglycerol lipase, Short name=Pancreatic lipase
• Sequence length: 465 AA.
• Catalytic activity: Triacylglycerol + H2O = diacylglycerol + a carboxylate.
• Sequence similarities: PNLIP belongs to the AB hydrolase superfamily. Lipase family. Contains 1 PLAT domain.
• Induction: By colipase/CLPS in the presence of bile salts.
• Subcellular location: Secreted.

General information above from UniProt

Function for PNLIP Protein

Genatlas:

• PNLIP encodes a carboxyl esterase that hydrolyzes insoluble, emulsified triglycerides, and is essential for the efficient digestion of dietary fats
• PNLIP and CEL serve complementary functions, working together to mediate the absorption of a major portion of dietary fat and fat-soluble vitamin esters
• PNLIP plays very important roles in the digestion and absorption of lipids
• PNLIP may potentially be involved in the pathophysiology of traumatic brain injury and may be implicated in the proliferation of astrocytes and the recovery of neurological outcomes
• predominant lipase secreted by the exocrine pancreas
• PNLIP's activity is restored by the addition of another pancreatic protein, colipase

Phenotype Information for PNLIP

• Gene/Locus: PNLIP, PNLIPD
• Phenotype: Pancreatic lipase deficiency

Phenotype Information for PNLIP from OMIM (Online Mendelian Inheritance in Man)