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PNLIP

PNLIP Protein & Antibody

Entrez Gene Summary for PNLIP


This PNLIP gene is a member of the lipase gene family. It encodes a carboxyl esterase that hydrolyzes insoluble, emulsified triglycerides, and is essential for the efficient digestion of dietary fats. This PNLIP gene is expressed specifically in the pancreas. [provided by RefSeq, Jul 2008]

OMIM-Description for PNLIP


Pancreatic lipase (EC 3.1.1.3), a 56-kD protein that hydrolyzes dietary long chain triglycerides to free fatty acids and monoacylglycerols, is essential for the intestinal absorption of fats. The activity of pancreatic lipase (PNLIP)is stimulated in the presence of intestinal bile salts by pancreatic colipase (120105) (summary by Lowe et al., 1989).

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Pancreatic lipase, also known as pancreatic triacylglycerol lipase (PNLIP), is secreted from thepancreas, and is the primary lipase (enzyme) that hydrolyzes (breaks down) dietary fat moleculesin the human digestive system, converting triglyceride substrates found in ingested oils tomonoglycerides and free fatty acids.
Triacylglycerol + 2 H2O 2-monoacylglycerol + 2 fatty acid anions
Bile salts secreted from the liver and stored in gallbladder are released into the duodenum where they coat and emulsify large fat droplets into smaller droplets, thus increasing the overall surface area of the fat, which allows the lipase to break apart the fat more effectively. The resultingmonomers (2 free fatty acids and one 2-monoacylglycerol) are then moved by way of peristalsisalong the small intestine to be absorbed into the lymphatic system by a specialized vessel called a lacteal. This PNLIP protein belongs to pancreatic lipase family.
PNLIP is unlike some pancreatic enzymes that are activated by proteolytic cleavage (e.g. trypsinogen), pancreatic lipase is secreted in its final form. However it only becomes efficient in the presence ofcolipase in the duodenum.
In humans, pancreatic lipase is encoded by the PNLIP gene.

PNLIP Alternative Names

PL,pancreatic triacylglycerol lipase,PNLIPD,PTL,RP11-33D13.1,triacylglycerol acylhydrolase, [human]
1810007A24Rik,pancreatic triacylglycerol lipase,pancreatic triglyceride lipase,PL,PTL, [mouse]

PNLIP Related Products

PNLIP Proteins

Product nameProduct name
Human PNLIP Protein (His Tag)

PNLIP Antibodies

Product nameProduct name
PNLIP Antibody, Rabbit PAbPNLIP Antibody, Rabbit PAb, Antigen Affinity Purified

PNLIP cDNA Clones

Product nameProduct name
Human PNLIP Gene cDNA Clone (full-length ORF Clone), expression ready, N-His-taggedCynomolgus monkey PNLIP Gene cDNA Clone (full-length ORF Clone), expression ready, untaggedCynomolgus monkey PNLIP Gene cDNA Clone (full-length ORF Clone), expression ready, N-His-taggedCynomolgus monkey PNLIP Gene cDNA Clone (full-length ORF Clone), expression ready, C-OFPSpark tagHuman PNLIP Gene cDNA Clone (full-length ORF Clone), expression ready, C-GFPSpark-taggedHuman PNLIP Gene cDNA Clone (full-length ORF Clone), expression ready, C-OFPSpark tagHuman PNLIP Gene cDNA Clone (full-length ORF Clone), expression ready, C-Myc-taggedCynomolgus monkey PNLIP Gene cDNA Clone (full-length ORF Clone), expression ready, N-FLAG-taggedCynomolgus monkey PNLIP Gene cDNA Clone (full-length ORF Clone), expression ready, C-Myc-taggedHuman PNLIP Gene cDNA Clone (full-length ORF Clone), expression ready, C-HA-taggedHuman PNLIP Gene cDNA Clone (full-length ORF Clone), expression ready, N-HA-taggedCynomolgus monkey PNLIP Gene cDNA Clone (full-length ORF Clone), expression ready, N-HA-taggedCynomolgus monkey PNLIP Gene cDNA Clone (full-length ORF Clone), expression ready, C-HA-taggedHuman PNLIP Gene cDNA Clone (full-length ORF Clone), expression ready, C-His-taggedCynomolgus monkey PNLIP Gene cDNA Clone (full-length ORF Clone), expression ready, C-His-taggedHuman PNLIP Gene cDNA Clone (full-length ORF Clone), expression ready, N-FLAG-taggedHuman PNLIP Gene cDNA Clone (full-length ORF Clone), expression ready, C-FLAG-taggedHuman PNLIP Gene cDNA Clone (full-length ORF Clone), expression ready, untaggedCynomolgus monkey PNLIP Gene cDNA Clone (full-length ORF Clone), expression ready, C-FLAG-taggedHuman PNLIP Gene cDNA Clone (full-length ORF Clone)Cynomolgus monkey PNLIP Gene cDNA Clone (full-length ORF Clone), expression ready, C-GFPSpark-taggedHuman PNLIP Gene cDNA Clone (full-length ORF Clone), expression ready, N-Myc-taggedCynomolgus monkey PNLIP Gene cDNA Clone (full-length ORF Clone)Cynomolgus monkey PNLIP Gene cDNA Clone (full-length ORF Clone), expression ready, N-Myc-tagged

PNLIP ELISA

Product nameProduct name
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"