PMP2

PMP2 may play a role in lipid transport protein in Schwann cells. PMP2 may bind cholesterol.

PMP2 Related Areas

Cardiovascular>>Lipid Metabolism>>PMP2

PMP2 Alternative Names

PMP2, FABP8, M-FABP, MP2, P2 [Homo sapiens]

Pmp2, MGC117795, P2 [Mus musculus]

Summaries for PMP2

Wikipedia summary for PMP2:

Myelin P2 protein is a protein that in humans is encoded by the PMP2 gene.

Human PMP2 Protein General Information

 

• Protein names: Peripheral myelin protein 2
  Short name=PMP2
• Sequence length: 132 AA.
• Domain: Forms a beta-barrel structure that accommodates hydrophobic ligands in its interior.
• Sequence similarities: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.
• Miscellaneous: P2 protein and myelin basic protein together constitute a major fraction of peripheral nervous system myelin protein.
• Subunit structure: Monomer.
• Subcellular location: Cytoplasm

General information above from UniProt

Function for PMP2 Protein

UniProtKB:

PMP2 may play a role in lipid transport protein in Schwann cells. PMP2 may bind cholesterol.

Genatlas:

• PMP2 is potentially involved in the transport of fatty acids or metabolism of myelin lipids
• PMP2 acts synergistically with MBP to cause stacking of lipid bilayers (Suresh 2010)
• PMP2 is lipid binding activity (Hayasaka 1991)
• PMP2 may play a role in lipid transport protein in Schwann cells
• PMP2 forms a beta-barrel structure that accomodates hydrophobic ligand in its interior

Homology for human PMP2

• homolog to murine Pmp2 (87.1pc)
• homolog to rattus Pmp2 (90.2pc)