PLK1 / PLK-1 Protein

Polo-Like Kinase 1

PLK1 / PLK-1 Products

PLK1 / PLK-1 Protein, Recombinant

Molecule	Species	Description	Cat. No
PLK1/PLK-1	Human	PLK1/PLK-1 Protein, Recombinant	10676-H07B
PLK1/PLK-1	Mouse	PLK1 / PLK-1 Protein, Recombinant	50624-M07B

PLK1 / PLK-1 cDNA Clone

Molecule	Species	Description	Cat. No
PLK1/PLK-1	Human	Homo sapiens PLK1/PLK-1 cDNA Clone	HG10676-M
PLK1/PLK-1	Mouse	Mus musculus PLK1/PLK-1 cDNA Clone	MG50624-M

PLK1 / PLK-1 Related Areas

Enzyme>>Protein Kinase>>Intracellular Kinase>>PLK1/PLK-1

Signal Transduction>>Protein Kinase>>Intracellular Kinase>>PLK1/PLK-1

PLK1 / PLK-1 Alternative Names

PLK1, PLK, STPK13 [Homo sapiens]

Plk1, Plk, STPK13 [Mus musculus]

PLK1 / PLK-1 Background

Serine / threonine-protein kinase PLK1 / PLK-1, also known as polo-like kinase 1 (PLK-1) or serine / threonine-protein kinase 13 (STPK13), Polo-like kinases (PLKs), is a family of four serine / threonine protein kinases that are critical regulators of cell cycle progression, mitosis, cytokinesis, and the DNA damage response. PLK1 / PLK-1 is ubiquitously expressed. The mRNA and protein expression of PLK1 / PLK-1, -2 and -4 are coordinately regulated during cell cycle progression, but PLK3 levels are independent of the other three family members. PLK1 / PLK-1 is the most well characterized member of this family and strongly promotes the progression of cells through mitosis. During the various stages of mitosis PLK1 / PLK-1 localizes to the centrosomes, kinetochores and central spindle. PLKs are dysregulated in a variety of human cancers. PLK1 / PLK-1 overexpression correlates with cellular proliferation and poor prognosis. Serine / threonine-protein kinase that performs several important functions throughout M phase of the cell cycle, including the regulation of centrosome maturation and spindle assembly, the removal of cohesins from chromosome arms, the inactivation of APC / C inhibitors, and the regulation of mitotic exit and cytokinesis. It is required for recovery after DNA damage checkpoint and entry into mitosis. PLK1 / PLK-1 is required for kinetochore localization of BUB1B, spindle pole localization of isoform 3 of SGOL1 and plays a role in regulating its centriole cohesion function. PLK1 / PLK-1 Phosphorylates BORA, and thereby promotes the degradation of BORA. PLK1 / PLK-1 also contributes to the regulation of AURKA function and phosphorylates SGOL1.

PLK1 / PLK-1 Related Studies

1. Lee KS, et al. (2008) Self-regulated mechanism of Plk1 localization to kinetochores: lessons from the Plk1-PBIP1 interaction. Cell Div. 3: 4.
2. Zhou T, et al. (2003) A role for Plk1 phosphorylation of NudC in cytokinesis. Dev Cell. 5 (1): 127–38.
3. Lee M, et al. (2004) Phosphorylation of BRCA2 by the Polo-like kinase Plk1 is regulated by DNA damage and mitotic progression. Oncogene. 23 (4): 865–72.