Anti-uPAR Antibody

Cat: 50160-R014
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Anti-uPAR Antibody (Rabbit Monoclonal antibody) General Information
Product name
Anti-uPAR Antibody
Validated applications
ELISA
Species reactivity
Reacts with: Mouse
Specificity
Mouse uPAR
Immunogen
Recombinant Mouse PLAUR / CD87 Protein (Catalog#50160-M08H)
Preparation
This antibody was obtained from a rabbit immunized with purified, recombinant Mouse PLAUR / CD87 (rM PLAUR / CD87; Catalog#50160-M08H; NP_035243.1; Met1-Thr297).
Source
Monoclonal Rabbit IgG Clone #014
Purification
Protein A
Formulation
0.2 μm filtered solution in PBS
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-uPAR Antibody (Rabbit Monoclonal antibody) Validated Applications
Application Dilution Notes
ELISA 1:5000-1:10000  

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-uPAR Antibody Alternative Names
Anti-Cd87 Antibody;Anti-u-PAR Antibody;Anti-uPAR Antibody
uPAR Background Information

Urokinase plasminogen activator (uPA) and/or its receptor (uPAR) are essential for metastasis, and overexpression of these molecules is strongly correlated with poor prognosis in a variety of malignant tumours. uPAR and uPA levels in both resected tumor tissue and plasma are of independent prognostic significance for patient survival in several types of human cancer. This system has classically been thought to drive tumor progression by mediating directed extracellular proteolysis on the surface of migrating or invading cells, and intervening with this proteolysis by targeting uPAR has been proposed to represent a novel approach for inhibiting tumor progression. uPAR, also known as PLAUR or CD87, has been implicated in the growth, metastasis, and angiogenesis of several solid and hemotologic malignancies. uPAR is a highly glycosylated, 55-60kDa integral membrane protein linked to the plasma membrane by a glycosylphosphatidylinositol (GPI) anchor. It is part of a cell surface system that also consists of the serine protease uPA and several specific inhibitors (plasminogen activator inhibitors 1 and 2). Additionally, the analysis of CD87 (urokinase-type plasminogen activator receptor - uPAR) expression has a potential role in the diagnostic or prognostic work-up of several hematological malignancies, particularly acute leukemia and multiple myeloma.

Full Name
plasminogen activator, urokinase receptor
References
  • Romer J, et al. (2004) The urokinase receptor as a potential target in cancer therapy. Curr Pharm Des. 10(19): 2359-76.
  • Bn MC, et al. (2004) CD87 (urokinase-type plasminogen activator receptor), function and pathology in hematological disorders: a review. Leukemia. 18(3): 394-400.
  • Pillay V, et al. (2007) The urokinase plasminogen activator receptor as a gene therapy target for cancer. Trends Biotechnol. 25(1): 33-9.
  • Mazar AP. (2008) Urokinase plasminogen activator receptor choreographs multiple ligand interactions: implications for tumor progression and therapy. Clin Cancer Res. 14(18): 5649-55.
  • Product Description Host Clonality Application Catalog# (PDF)
    Anti-uPAR Antibody Rabbit Polyclonal IHC-P 102261-T08
    Anti-uPAR Antibody Rabbit Polyclonal ELISA 50160-RP01
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    Anti-uPAR Antibody Mouse Monoclonal ELISA(Cap) 10925-MM04
    Anti-uPAR Antibody Mouse Monoclonal ELISA 10925-MM08
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    Anti-uPAR Antibody Mouse Monoclonal ELISA(Det) 10925-MM05
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    Anti-uPAR Antibody Rabbit Polyclonal ELISA 10925-RP01
    Anti-uPAR Antibody (APC) Mouse Monoclonal FCM 10925-MM09-A
    Anti-uPAR Antibody (PE) Mouse Monoclonal FCM 10925-MM05T-P
    Anti-uPAR Antibody (FITC) Mouse Monoclonal FCM 10925-MM05T-F
    Anti-uPAR Antibody Mouse Monoclonal FCM 10925-MM05T
    Anti-uPAR Antibody (PE) Mouse Monoclonal FCM 10925-MM09-P
    Anti-uPAR Antibody Mouse Monoclonal FCM 10925-MM09
    Anti-uPAR Antibody (FITC) Mouse Monoclonal FCM 10925-MM09-F
    Anti-uPAR Antibody Rabbit Monoclonal ELISA 10925-R103
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