Our new search engine has been launched. Welcome to use it and experience it. If you have any suggestions, welcome to contact us!
Text Size:AAA

PLA2G2E  Protein, Antibody, ELISA Kit, cDNA Clone

PLA2G2E Related Pathways

PLA2G2E Related Protein, Antibody, cDNA Gene, and ELISA Kits

PLA2G2E Related Protein, Antibody, cDNA Gene, and ELISA Kits

Featured Reagent Products

PLA2G2E Summary & Protein Information

PLA2G2E Background

Catalytic activity: Phosphatidylcholine + H(2)O = 1- acylglycerophosphocholine + a carboxylate.
Cofactor: Binds 1 calcium ion per subunit.
Subcellular location: Secreted.
Tissue specificity: Restricted to the brain, heart, lung, and placenta.
Sequence similarity: Belongs to the phospholipase A2 family.C
General information above from UniProt

Mouse Group IIE secretory phospholipase A2, also known as GIIE sPLA2, sPLA2-IIE, Phosphatidylcholine 2-acylhydrolase 2E and PLA2G2E is a secreted protein which belongs to the phospholipase A2 family. Mammalian secretory phospholipase A2s ( sPLA2s ) form a family of structurally related enzymes that are involved in a variety of physiological and pathological processes via the release of arachidonic acid from membrane phospholipids or the binding to specific membrane receptors. Phospholipases A2 / PLA2 are enzymes that release fatty acids from the second carbon group of glycerol. This particular phospholipase specifically recognizes the sn-2 acyl bond of phospholipids and catalytically hydrolyzes the bond releasing arachidonic acid and lysophospholipids. Phospholipases A2 / PLA2 are commonly found in mammalian tissues as well as insect and snake venom. Venom from both snakes and insects is largely composed of melittin, which is a stimulant of Phospholipases A2 / PLA2. Due to the increased presence and activity of Phospholipases A2 / PLA2 resulting from a snake or insect bite, arachidonic acid is released from the phospholipid membrane disproportionately. As a result, inflammation and pain occur at the site. PLA2G2E catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides. Has a preference for arachidonic-containing phospholipids.

PLA2G2E Alternative Name

sPLA2-IIE,GIIEsPLA2, [homo-sapiens]
GIIE sPLA2,OTTHUMP00000002789,PLA2G2E, [human]
PLA2G2E,RP23-352K10.7, [mouse]

PLA2G2E Related Studies

  • Dennis EA. et al.,1994, J. Biol. Chem. 269 (18): 13057-60. 
  • Nicolas JP, et al.,1997, J. Biol. Chem. 272 (11): 7173-81.
  • Six DA, et al., 2000, Biochim. Biophys. Acta 1488 (1-2): 1-19.
  • Suzuki N., et al., 2000,J. Biol. Chem. 275:5785-93.
  • Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"