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PLA2G2E  Protein, Antibody, ELISA Kit, cDNA Clone

PLA2G2E Related Pathways

PLA2G2E Related Protein, Antibody, cDNA Gene, and ELISA Kits

PLA2G2E Related Protein, Antibody, cDNA Gene, and ELISA Kits

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PLA2G2E Summary & Protein Information

PLA2G2E Background

Catalytic activity: Phosphatidylcholine + H(2)O = 1- acylglycerophosphocholine + a carboxylate.
Cofactor: Binds 1 calcium ion per subunit.
Subcellular location: Secreted.
Tissue specificity: Restricted to the brain, heart, lung, and placenta.
Sequence similarity: Belongs to the phospholipase A2 family.C
General information above from UniProt

Mouse Group IIE secretory phospholipase A2, also known as GIIE sPLA2, sPLA2-IIE, Phosphatidylcholine 2-acylhydrolase 2E and PLA2G2E is a secreted protein which belongs to the phospholipase A2 family. Mammalian secretory phospholipase A2s ( sPLA2s ) form a family of structurally related enzymes that are involved in a variety of physiological and pathological processes via the release of arachidonic acid from membrane phospholipids or the binding to specific membrane receptors. Phospholipases A2 / PLA2 are enzymes that release fatty acids from the second carbon group of glycerol. This particular phospholipase specifically recognizes the sn-2 acyl bond of phospholipids and catalytically hydrolyzes the bond releasing arachidonic acid and lysophospholipids. Phospholipases A2 / PLA2 are commonly found in mammalian tissues as well as insect and snake venom. Venom from both snakes and insects is largely composed of melittin, which is a stimulant of Phospholipases A2 / PLA2. Due to the increased presence and activity of Phospholipases A2 / PLA2 resulting from a snake or insect bite, arachidonic acid is released from the phospholipid membrane disproportionately. As a result, inflammation and pain occur at the site. PLA2G2E catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides. Has a preference for arachidonic-containing phospholipids.

PLA2G2E Alternative Name

sPLA2-IIE,GIIEsPLA2, [homo-sapiens]
GIIE sPLA2,OTTHUMP00000002789,PLA2G2E, [human]
PLA2G2E,RP23-352K10.7, [mouse]

PLA2G2E Related Studies

  • Dennis EA. et al.,1994, J. Biol. Chem. 269 (18): 13057-60. 
  • Nicolas JP, et al.,1997, J. Biol. Chem. 272 (11): 7173-81.
  • Six DA, et al., 2000, Biochim. Biophys. Acta 1488 (1-2): 1-19.
  • Suzuki N., et al., 2000,J. Biol. Chem. 275:5785-93.