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PLA2G12B  Protein, Antibody, ELISA Kit, cDNA Clone

PLA2G12B Related Area

PLA2G12B Related Pathways

    PLA2G12B Summary & Protein Information

    PLA2G12B Background

    Gene Summary: Phospholipase A2 (PLA2) enzymes catalyze hydrolysis of glycolipids to release free fatty acids and lysophospholipids. PLA2G12B belongs to the PLA2 family, but it is catalytically inactive due to an amino acid change in its active site and has altered phospholipid-binding properties (Rouault et al., 2003 ).[supplied by OMIM, Mar 2008]
    General information above from NCBI
    Cofactor: Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence={ECO:0000250}; ; Note=Binds 1 Ca(2+) ion per subunit. {ECO:0000250};
    Subcellular location: Secreted.
    Tissue specificity: Strong expression in liver, small intestine and kidney. {ECO:0000269|PubMed:14516201}.
    Sequence similarity: Belongs to the phospholipase A2 family. {ECO:0000305}.
    General information above from UniProt

    Group XIIB secretory phospholipase A2-like protein, also known as Group XIII secretory phospholipase A2-like protein, GXIII sPLA2-like, sPLA2-GXIIB, GXIIB, PLA2G13 and PLA2G12B, is a secreted protein which belongs to the phospholipase A2 family. PLA2G12B / PLA2G13 is strong expression in liver, small intestine and kidney. Mammalian secretory phospholipase A2s ( sPLA2s ) form a family of structurally related enzymes that are involved in a variety of physiological and pathological processes via the release of arachidonic acid from membrane phospholipids or the binding to specific membrane receptors. Phospholipases A2 / PLA2 are enzymes that release fatty acids from the second carbon group of glycerol. This particular phospholipase specifically recognizes the sn-2 acyl bond of phospholipids and catalytically hydrolyzes the bond releasing arachidonic acid and lysophospholipids. Phospholipases A2 / PLA2 are commonly found in mammalian tissues as well as insect and snake venom. Venom from both snakes and insects is largely composed of melittin, which is a stimulant of Phospholipases A2 / PLA2. Due to the increased presence and activity of Phospholipases A2 / PLA2 resulting from a snake or insect bite, arachidonic acid is released from the phospholipid membrane disproportionately. As a result, inflammation and pain occur at the site.

    PLA2G12B Alternative Name

    GXIIB,FKSG71,PLA2G13,GXIIIsPLA2, [homo-sapiens]
    FKSG71,GXIIB,GXIIIsPLA2,MGC138151,PLA2G12B,PLA2G13, [human]
    2010002E04Rik,Fksg71,PLA2G12B,Pla2g13, [mouse]
    Fksg71,hlb218,Pla2g13,2010002E04Rik, [mus-musculus]

    PLA2G12B Related Studies

  • Dennis EA. et al.,1994, J. Biol. Chem. 269 (18): 13057-60. 
  • Nicolas JP, et al.,1997, J. Biol. Chem. 272 (11): 7173-81.
  • Six DA, et al., 2000, Biochim. Biophys. Acta 1488 (1-2): 1-19.
  • Mounier,C.M. et al., 2008, Br J Cancer. 98 (3):587-95.