PKC delta Protein

Protein Kinase C, delta

PKC delta Products

PKC delta Protein, Recombinant

Molecule	Species	Description	Cat. No
PKC delta	Mouse	PKC delta Protein, Recombinant, with GST Tag	50345-M20B

PKC delta cDNA Clone

Molecule	Species	Description	Cat. No
PKC delta	Human	Human PKC delta/PRKCD cDNA Clone / ORF Clone	HG10769-M
PKC delta	Mouse	Mouse PKC delta/PRKCD cDNA Clone / ORF Clone	MG50345-M

PKC delta Related Areas

Stem Cell>>Wnt Signaling Pathway>>Non-Canonical Wnt Pathway>>PKC delta

Neuroscience>>Axon Guidance>>Wnt Signaling Pathway>>PKC delta

Enzyme>>Protein Kinase>>Intracellular Kinase>>Protein Kinase C (PKC)>>PKC delta

Signal Transduction>>Wnt Signaling Pathway>>Non-Canonical Wnt Pathway>>PKC delta

Signal Transduction>>Protein Kinase>>Intracellular Kinase>>Protein Kinase C (PKC)>>PKC delta

PKC delta Alternative Names

PKC delta, PRKCD, MAY1, MGC49908, PKCD, nPKC-delta [Homo sapiens]

PKC delta, Prkcd, AI385711, D14Ertd420e, PKC[d], PKCdelta, Pkcd [Mus musculus]

PKC delta Background

Protein kinase C also known as PKC Protein kinase C (PKC) refers to a family of serine / threonine protein kinases grouped by their activation mechanism. Classical or conventional PKCs (cPKC alpha-, betaI- , betaII- and gamma-) are activated by phosphatidylserine in a calcium dependent manner and can bind diacylglycerol (DAG). The Ca²⁺ insensitive novel PKCs (PKC delta-, epsilon-, theta- and eta- isotypes) are also activated by DAG and phosphatidylserine. The atypical PKCs (aPKCs iota- and zeta-) are insensitive to Ca²⁺, DAG and phorbol esters. All PKCs isoforms (such as PKC delta) consist of a highly conserved catalytic domain connected to a regulatory domain via a hinge region. The physiological roles of PKCs are vast. This due to PKC phosphorylation and activation of multiple target proteins, which are involved in signal transduction pathways including, but not limited to, receptor desensitization, modulation of membrane structure events, regulation of transcription, regulation of cell growth, immune responses, and in learning and memory. This is calcium-independent, phospholipid-dependent, serine- and threonine-specific enzyme. PKC delta is activated by diacylglycerol which in turn phosphorylates a range of cellular proteins. PKC also serves as the receptor for phorbol esters, a class of tumor promoters. PKC delta May play a role in antigen-dependent control of B-cell function. Phosphorylates MUC1 in the C-terminal and regulates the interaction between MUC1 and beta-catenin.

PKC delta Related Studies

1. Cross T, et al. (2000) PKC-delta is an apoptotic lamin kinase. Oncogene. 19(19): 2331-7.
2. Song JS, et al. (1998) Tyrosine phosphorylation-dependent and -independent associations of protein kinase C-delta with Src family kinases in the RBL-2H3 mast cell line: regulation of Src family kinase activity by protein kinase C-delta. Oncogene. 16(26): 3357-68.
3. Shanmugam M, et al. (1998) Association of PKC delta and active Src in PMA-treated MCF-7 human breast cancer cells. Oncogene. 16(13): 1649-54.