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PIK3CB  Protein, Antibody, ELISA Kit, cDNA Clone

PIK3CB Related Pathways

PIK3CB Related Protein, Antibody, cDNA Gene, and ELISA Kits

PIK3CB Summary & Protein Information

PIK3CB Background

Catalytic activity: ATP + 1-phosphatidyl-1D-myo-inositol 4,5- bisphosphate = ADP + 1-phosphatidyl-1D-myo-inositol 3,4,5- trisphosphate.
Subunit structure: Heterodimer of a catalytic subunit PIK3CB and a p85 regulatory subunit (PIK3R1, PIK3R2 or PIK3R3). Interaction with PIK3R2 is required for nuclear localization and nuclear export. Part of a complex with PIK3R1 and PTEN. Binding to PTEN may antagonize the lipid kinase activity under normal growth conditions. Part of a complex involved in autophagosome formation composed of PIK3C3 and PIK3R4 (By similarity). Interacts with BECN1, ATG14 and RAB5A (By similarity).
Domain: The inhibitory interactions with PIK3R1 are mediated by the PI3K-ABD domain and the C2 PI3K-type domain with the iSH2 (inter-SH2) region of PIK3R1; the C2 PI3K-type domain, the PI3K helical domain, and the PI3K/PI4K kinase domain with the nSH2 (N- terminal SH2) region of PIK3R1; and the PI3K/PI4K kinase domain with the cSH2 (C-terminal SH2) region of PIK3R1. The inhibitory interaction between the PI3K-ABD domain and the C2 PI3K-type domain with the iSH2 (inter-SH2) region of PIK3R1 is weak. The nuclear localization signal (NLS) is required for its function in cell survival.
Subcellular location: Cytoplasm. Nucleus. Note=Interaction with PIK3R2 is required for nuclear localization and export.
Tissue specificity: Expressed ubiquitously.
Post-translational: Phosphorylation at Ser-1070 down-regulates lipid kinase activity.
Sequence similarity: Belongs to the PI3/PI4-kinase family.
Contains 1 C2 PI3K-type domain.
Contains 1 PI3K-ABD domain.
Contains 1 PI3K-RBD domain.
Contains 1 PI3K/PI4K domain.
Contains 1 PIK helical domain.C
General information above from UniProt

PIK3CB Alternative Name

PI3K,PIK3C1,P110BETA,PI3KBETA, [homo-sapiens]
AI447572,p110beta,1110001J02Rik, [mus-musculus]

PIK3CB Related Studies

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