|Recombinant Mouse PIGR protein (Catalog#50119-M08H)|
|0.2 μm filtered solution in PBS|
|This antibody was obtained from a rabbit immunized with purified, recombinant Mouse PIGR extracellular domain (rM PIGR; Catalog#50119-M08H; NP_035212.2; Met 1-Lys 645).|
ELISA: 0.1-0.2 μg/mL
This antibody can be used at 0.1-0.2 μg/mL with the appropriate secondary reagents to detect Mouse PIGR. The detection limit for Mouse PIGR is approximately 0.00245 ng/well.
ELISA(Cap): 0.5-4 µg/ml
This antibody will detect Mouse PIGR in ELISA pair set (Catalog: # SEK50119). In a sandwich ELISA, it can be used as capture antibody.
Polymeric immunoglobulin receptor, also known as PIGR, is a member of the immunoglobulin superfamily and a Fc receptor. The ectodomain of this receptor consists of five units with homology to the variable units of immunoglobulins and a transmembrane region, which also has some homology to certain immunoglobulin variable regions. PIGR is expressed on several glandular epithelia including those of liver and breast. The deduced amino-acid sequence has a length of 764 residues and shows an overall similarity of 56% and 64% with the rabbit and rat counterpart. PIGR mediates transcellular transport of polymeric immunoglobulin molecules, and thus facilitates the secretion of IgA and IgM. During this process, a cleavage occurs that separates the extracellular (known as the secretory component) from the transmembrane segment of PIGR.