PIGF / PLGF Protein

Placental growth factor

PIGF / PLGF Products

PIGF / PLGF Protein, Recombinant

Molecule	Species	Description	Cat. No
PIGF/PLGF	Mouse	PIGF/PLGF Protein, Recombinant	50125-M02H

PIGF / PLGF cDNA Clone

Molecule	Species	Description	Cat. No
PIGF/PLGF	Human	Human PGF/PLGF cDNA Clone / ORF Clone	HG10274-M
PIGF/PLGF	Mouse	Mouse PGF/PLGF cDNA Clone / ORF Clone	MG50125-M

PIGF / PLGF Related Areas

Cancer>>Growth factor & Receptor>>VEGF & Receptor>>PIGF/PLGF

PIGF / PLGF Alternative Names

PIGF, PLGF, PGF, D12S1900, PLGF-2, SHGC-10760 [Homo sapiens]

PIGF, PLGF, Pgf, AI854365 [Mus musculus]

PIGF / PLGF Background

Placental growth factor (PGF), also known as PIGF, PLGF, is an angiogenic factor that belongs to the vascular endothelial growth factor (VEGF) family. Besides its well known capacity to potentiate the angiogenic action of VEGF, PlGF also participates in inflammatory processes by attracting and activating monocytes. PIGF/PLGF plays therefore more specifically a role in pathological conditions. PIGF and its two receptors, VEGFR-1 and neuropilins (NRPs), are expressed in the brain and increase after experimental stroke. PlGF play an important role in promoting adult pathological angiogenesis. Moreover, PlGF expression by melanoma cells has been linked to tumor growth. PlGF is being considered for therapeutic relief of coronary heart disease and other forms of tissue ischemia caused by atherosclerosis.

PIGF / PLGF Related Studies

1. Nagy JA, et al. (2003) VEGF-A(164/165) and PlGF: roles in angiogenesis and arteriogenesis. Trends Cardiovasc Med. 13(5): 169-75.
2. Chaballe L, et al. (2011) Placental growth factor: a tissue modelling factor with therapeutic potentials in neurology? Acta Neurol Belg. 111(1): 10-7.
3. Odorisio T, et al. (2006) The placenta growth factor in skin angiogenesis. J Dermatol Sci. 41(1): 11-9.