Anti-PHPT1 Antibody

Cat: 12473-RP01
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Anti-PHPT1 Antibody (Rabbit Polyclonal antibody) General Information
Product name
Anti-PHPT1 Antibody
Validated applications
ELISA
Species reactivity
Reacts with: Human
Specificity
Human PHPT1
Immunogen
Recombinant Human PHPT1 protein (Catalog#12473-H07E)
Preparation
Produced in rabbits immunized with purified, recombinant Human PHPT1 (rh PHPT1; Catalog#12473-H07E; Q9NRX4-1; Ala2-Tyr125). Total IgG was purified by Protein A affinity chromatography.
Source
Polyclonal Rabbit IgG
Purification
Protein A
Formulation
0.2 μm filtered solution in PBS with 5% trehalose
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-PHPT1 Antibody (Rabbit Polyclonal antibody) Validated Applications
Application Dilution Notes
ELISA 1:1000-1:2000  

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-PHPT1 Antibody Alternative Names
Anti-CGI-202 Antibody;Anti-HEL-S-132P Antibody;Anti-HSPC141 Antibody;Anti-PHP14 Antibody
PHPT1 Background Information

PHPT1, also known as 14 kDa phosphohistidine phosphatase, phosphohistidine phosphatase 1, protein janus-A homolog, PHP14, is a cytoplasm protein which belongs to the janus family. PHPT1 / PHP14 is expressed abundantly in heart and skeletal muscle. Phosphatases are a diverse group of enzymes that regulate numerous cellular processes. Much of what is known relates to the tyrosine, threonine, and serine phosphatases, whereas the histidine phosphatases have not been studied as much. Protein histidine phosphorylation exists widely in vertebrates, and it plays important roles in signal transduction and other cellular functions. Protein histidine phosphorylation accounts for about 6% of the total protein phosphorylation in eukaryotic cells. The knowledge about eukaryotic PHPT (protein histidine phosphatase) is still very limited. To date, only one vertebrate PHPT has been discovered, and two crystal structures of human PHPT1 have been solved. PHPT1 / PHP14 can dephosphorylate a variety of proteins (e.g. ATP-citrate lyase and the beta-subunit of G proteins). A putative active site has been identified by its electrostatic character, ion binding, and conserved protein residues.

Full Name
phosphohistidine phosphatase 1
References
  • Busam,R.D. et al., 2006, J Biol Chem. 281 (45):33830-4.
  • Zhang,X.Q. et al., 2009, Ups J Med Sci.114 (2):65-72.
  • Gong,W. et al., 2009, Biochem J. 418 (2):337-44.
  • Chapin,L.J. et al., 2009, J Exp Bot. 60 (7):2179-90.
  • Product Description Host Clonality Application Catalog# (PDF)
    Anti-PHPT1 Antibody Rabbit Monoclonal IHC-P,FCM,ICC/IF,IF 12473-R001
    Anti-PHPT1 Antibody Mouse Monoclonal ELISA,ELISA(Det) 12473-MM01
    Anti-PHPT1 Antibody Mouse Monoclonal ELISA(Cap) 12473-MM11
    Anti-PHPT1 Antibody Rabbit Monoclonal ELISA 12473-R009
    Anti-PHPT1 Antibody Rabbit Polyclonal WB,ELISA,IHC-P,IP 12473-RP02
    Anti-PHPT1 Antibody Rabbit Monoclonal WB 12473-R007
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