Phosphatase, orphan 1
PHOSPHO1 Protein, Recombinant
|Molecule||Species||Description //For Detailed Info. and Price------CLICK!||Cat No|
|PHOSPHO1||Human||PHOSPHO1 Protein, Recombinant||13187-H07E|
PHOSPHO1 Related Areas
Signal Transduction>>Phosphatase & Regulator>> PHOSPHO1
PHOSPHO1 Alternative Names
OTTHUMP00000220006, OTTHUMP00000220008, OTTHUMP00000220009[Homo sapiens]
RP23-151M22.3, D11Moh36, Phospo1[Mus musculus]
PHOSPHO1 is a phosphatase whose expression is upregulated in mineralizing cells and is implicated in the generation of inorganic phosphate for matrix mineralization, a process central to skeletal development. PHOSPHO1 belongs to the haloacid dehalogenase superfamily of hydrolases and is a phosphatase highly expressed in bone. It localization is restricted to mineralizing regions of bone and growth plate and that the enzyme present within MVs is in an active state, inhibition of which decreases the capacity of MVs to mineralize. This phosphatase is capable of cleaving phosphoethanolamine (PEA) and phosphocholine to generate inorganic phosphate. PHOSPHO1 plays a role in the initiation of matrix mineralization.
PHOSPHO1 Related Studies
- Stewart AJ, et al. (2003) Comparative modelling of human PHOSPHO1 reveals a new group of phosphatases within the haloacid dehalogenase superfamily. Protein Eng. 16(12): 889-95.
- Camps M, et al. (2000) Dual specificity phosphatases: a gene family for control of MAP kinase function. FASEB J. 14(1): 6-16.
- Barford D. (1996) Molecular mechanisms of the protein serine/threonine phosphatases. Trends Biochem Sci. 21(11): 407-12.