PHOSPHO1 Protein

Phosphatase, orphan 1

 PHOSPHO1 Products

 PHOSPHO1 Protein, Recombinant

Molecule	Species	Description	Cat No
PHOSPHO1	Human	PHOSPHO1 Protein, Recombinant	13187-H07E

 PHOSPHO1 Related Areas

Enzyme>>Phosphatase & Regulator>> PHOSPHO1

Signal Transduction>>Phosphatase & Regulator>> PHOSPHO1

 PHOSPHO1 Alternative Names

OTTHUMP00000220006, OTTHUMP00000220008, OTTHUMP00000220009[Homo sapiens]

RP23-151M22.3, D11Moh36, Phospo1[Mus musculus]

 PHOSPHO1 Background

PHOSPHO1 is a phosphatase whose expression is upregulated in mineralizing cells and is implicated in the generation of inorganic phosphate for matrix mineralization, a process central to skeletal development. PHOSPHO1 belongs to the haloacid dehalogenase superfamily of hydrolases and is a phosphatase highly expressed in bone. It localization is restricted to mineralizing regions of bone and growth plate and that the enzyme present within MVs is in an active state, inhibition of which decreases the capacity of MVs to mineralize. This phosphatase is capable of cleaving phosphoethanolamine (PEA) and phosphocholine to generate inorganic phosphate. PHOSPHO1 plays a role in the initiation of matrix mineralization.

 PHOSPHO1 Related Studies

1. Stewart AJ, et al. (2003) Comparative modelling of human PHOSPHO1 reveals a new group of phosphatases within the haloacid dehalogenase superfamily. Protein Eng. 16(12): 889-95.
2. Camps M, et al. (2000) Dual specificity phosphatases: a gene family for control of MAP kinase function. FASEB J. 14(1): 6-16.
3. Barford D. (1996) Molecular mechanisms of the protein serine/threonine phosphatases. Trends Biochem Sci. 21(11): 407-12.