>Human Cell Expressed
>Mouse PGRL / IGSF8 Protein (His Tag)
|Catalog||Size (Price)||Quantity||In Stock||Operation||Other Information|
Immunoglobulin superfamily, member 8 Protein Datasheet
PGRL / IGSF8 Protein Price Inquiry ( Available Sizes )
PGRL / IGSF8 Protein Product Information
|Synonym :||IGSF8, Ewi2, Kct4, Pgrl|
A DNA sequence encoding the mouse IGSF8 (AAH48387.1) (Met1-Thr577) was expressed with a C-terminal polyhistidine tag.
|Expression Host:||Human Cells|
PGRL / IGSF8 Protein QC Testing
|Purity:||> 95% as determined by SDS-PAGE||SDS-PAGE:
PGRL / IGSF8 protein
|Endotoxin:||< 1.0 EU per μg of the protein as determined by the LAL method|
|Stability:||Samples are stable for up to twelve months from date of receipt at -70℃|
|Predicted N terminal:||Arg 26|
The recombinant mouse IGSF8 comprises 563 amino acids and has a predicted molecular mass of 60.2 kDa. The apparent molecular mass of the protein is approximately 66 kDa in SDS-PAGE under reducing conditions due to glycosylation.
|Formulation:||Lyophilized from sterile PBS, pH7.4.
PGRL / IGSF8 Protein Usage Guide
|Storage:||Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.|
|Reconstitution:||A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.|
PGRL / IGSF8 Protein Related Products & Topics
|Molecule||Species||Description //For Detailed Info. and Price------CLICK!||Cat. No|
|PGRL / IGSF8||Mouse||PGRL / IGSF8 Protein, Recombinant||51042-M02H|
|PGRL / IGSF8||Mouse||PGRL / IGSF8 Protein, Recombinant||51042-M08H|
PGRL / IGSF8 Protein Description
Immunoglobulin superfamily member 8, also known as IGSF8, PGRL, and CD316, is a single-pass membrane protein with a short cytoplasmic domain interacting with membrane PIPs and mediating plasma membrane localization. It is expressed in brain, kidney, testic, liver and placenta with moderate expression in all other tissues. This protein has been detected on a majority of B-cells, T-cells, and nature killer cells but not on monocytes, polynuclear cells and platelets. IGSF8 may play a role in diverse functions ascribed to CD81 and CD9 such as oocytes fertilization or hepatitis C virus function. It also regulate proliferation and differentiation of keratinocytes. IGSF8 may be a negative regulator of cell motility: suppresses T-cell mobility coordinately with CD81, associates with CD82 to suppress prostate cancer cell migration, regulates epidermoid cell reaggregation and motility on laminin-5 with CD9 and CD81 as key linkers. It may also play a role on integrin-dependent morphology and motility functions and participate in the regulation of neurite outgrowth and maintenance of the neural network in the adult brain.
- Glazar AI. et al., 2009, Reprod Fertil Dev. 21 (2): 293-303.
- Murdoch JN. et al., 2003, Mol Cell Neurosci. 22 (1): 62-74.
- Zhang XA. et al., 2003, Cancer Res. 63 (10): 2665-74.