PGRL / IGSF8 Protein Price Inquiry ( Available Sizes )
PGRL / IGSF8 Protein Product Information
||AA033172, AU041109, ESTM34, EWI-2, KCT-4, PGRL, R75384
||A DNA sequence encoding the mouse IGSF8 (NP_536344.1) extracellulkar domain (Met 1-Thr 577) was fused with the Fc region of human IgG1 at the C-terminus.
PGRL / IGSF8 Protein QC Testing
||> 90 % as determined by SDS-PAGE.
PGRL / IGSF8 protein
||< 1.0 EU per μg of the protein as determined by the LAL method
||Samples are stable for up to twelve months from date of receipt at -70℃
|Predicted N terminal:
||The secreted recombinant mouse IGSF8/Fc is a disulfide-linked homodimer. The reduced monomer comprises 793 amino acids and has a calculated molecular mass of 85.8 kDa. The apparent molecular mass of the monomer is approximately 80 kDa in SDS-PAGE under reducing conditions.
||Lyophilized from sterile PBS , pH 7.4
- Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
- Please contact us for any concerns or special requirements.
PGRL / IGSF8 Protein Usage Guide
||Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
||A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
PGRL / IGSF8 Protein Related Products & Topics
PGRL / IGSF8 Protein Description
Immunoglobulin superfamily member 8, also known as IGSF8, PGRL, and CD316, is a single-pass membrane protein with a short cytoplasmic domain interacting with membrane PIPs and mediating plasma membrane localization. It is expressed in brain, kidney, testic, liver and placenta with moderate expression in all other tissues. This protein has been detected on a majority of B-cells, T-cells, and nature killer cells but not on monocytes, polynuclear cells and platelets. IGSF8 may play a role in diverse functions ascribed to CD81 and CD9 such as oocytes fertilization or hepatitis C virus function. It also regulate proliferation and differentiation of keratinocytes. IGSF8 may be a negative regulator of cell motility: suppresses T-cell mobility coordinately with CD81, associates with CD82 to suppress prostate cancer cell migration, regulates epidermoid cell reaggregation and motility on laminin-5 with CD9 and CD81 as key linkers. It may also play a role on integrin-dependent morphology and motility functions and participate in the regulation of neurite outgrowth and maintenance of the neural network in the adult brain.
- Glazar AI. et al., 2009, Reprod Fertil Dev. 21 (2): 293-303.
- Murdoch JN. et al., 2003, Mol Cell Neurosci. 22 (1): 62-74.
- Zhang XA. et al., 2003, Cancer Res. 63 (10): 2665-74.