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PGK1 Protein, Antibody, ELISA Kit, cDNA Clone

PGK1 Related Areas

PGK1 Related Pathways

PGK1 Related Protein, Antibody, cDNA Gene, and ELISA Kits

PGK1 Related Protein, Antibody, cDNA Gene, and ELISA Kits

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PGK1 Summary & Protein Information

PGK1 Background

Gene Summary: The protein encoded by PGK1 gene is a glycolytic enzyme that catalyzes the conversion of 1,3-diphosphoglycerate to 3-phosphoglycerate. The encoded protein may also act as a cofactor for polymerase alpha. PGK1 gene lies on the X-chromosome, while a related pseudogene also has been found on the X-chromosome and another on chromosome 19. [provided by RefSeq, Oct 2008]
General information above from NCBI
Catalytic activity: ATP + 3-phospho-D-glycerate = ADP + 3-phospho- D-glyceroyl phosphate.
Cofactor: Thiamine pyrophosphate.
Subunit structure: Monomer.
Subcellular location: Cytoplasm.
Involvement in disease: Phosphoglycerate kinase 1 deficiency (PGK1D) [MIM:300653]: A condition with a highly variable clinical phenotype that includes hemolytic anemia, rhabdomyolysis, myopathy and neurologic involvement. Patients can express one or more of these manifestations. Note=The disease is caused by mutations affecting the gene represented in this entry.
Sequence similarity: Belongs to the phosphoglycerate kinase family.
General information above from UniProt

PGK1 Alternative Name

PGKA,MIG10,HEL-S-68p, [homo-sapiens]
MGC8947,MGC117307,MGC142128,MIG10,PGK1,PGKA,RP4-570L12.1, [human]
Pgk1,MGC118097,Pgk-1, [mouse]
Pgk-1, [mus-musculus]

PGK1 Related Studies

  • Rush J. et al., 2005, Nat Biotechnol. 23: 94-101.
  • Olsen JV. et al., 2006, Cell. 127: 635-648.
  • Zieker D. et al., 2008, Cell Physiol Biochem. 21 (5-6): 429-36.
  • Jung Y. et al., 2009, Mol Cancer Res. 7 (10): 1595-604.
  • Choudhary C. et al., 2009, Science. 325: 834-40.
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