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PGK1 Protein, Antibody, ELISA Kit, cDNA Clone

PGK1 Related Areas

PGK1 Related Pathways

PGK1 Related Product

    PGK1 Summary & Protein Information

    PGK1 Background

    Gene Summary: The protein encoded by PGK1 gene is a glycolytic enzyme that catalyzes the conversion of 1,3-diphosphoglycerate to 3-phosphoglycerate. The encoded protein may also act as a cofactor for polymerase alpha. PGK1 gene lies on the X-chromosome, while a related pseudogene also has been found on the X-chromosome and another on chromosome 19. [provided by RefSeq, Oct 2008]
    General information above from NCBI
    Catalytic activity: ATP + 3-phospho-D-glycerate = ADP + 3-phospho- D-glyceroyl phosphate.
    Cofactor: Thiamine pyrophosphate.
    Subunit structure: Monomer.
    Subcellular location: Cytoplasm.
    Involvement in disease: Phosphoglycerate kinase 1 deficiency (PGK1D) [MIM:300653]: A condition with a highly variable clinical phenotype that includes hemolytic anemia, rhabdomyolysis, myopathy and neurologic involvement. Patients can express one or more of these manifestations. Note=The disease is caused by mutations affecting the gene represented in this entry.
    Sequence similarity: Belongs to the phosphoglycerate kinase family.
    General information above from UniProt

    PGK1 Alternative Name

    MGC8947,MGC117307,MGC142128,MIG10,PGK1,PGKA,RP4-570L12.1, [human]
    Pgk1,MGC118097,Pgk-1, [mouse]

    PGK1 Related Studies

  • Rush J. et al., 2005, Nat Biotechnol. 23: 94-101.
  • Olsen JV. et al., 2006, Cell. 127: 635-648.
  • Zieker D. et al., 2008, Cell Physiol Biochem. 21 (5-6): 429-36.
  • Jung Y. et al., 2009, Mol Cancer Res. 7 (10): 1595-604.
  • Choudhary C. et al., 2009, Science. 325: 834-40.
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