PGD / Phosphogluconate dehydrogenase Protein

PGD / Phosphogluconate dehydrogenase Products

PGD / Phosphogluconate dehydrogenase Protein, Recombinant

Molecule	Species	Description	Cat. No
PGD/Phosphogluconate dehydrogenase	Human	PGD/Phosphogluconate dehydrogenase Protein, Recombinant	10393-H07E

PGD / Phosphogluconate dehydrogenase cDNA Clone

Molecule	Species	Description	Cat. No
PGD/Phosphogluconate dehydrogenase	Human	PTGDS/PGD cDNA Clone / ORF Clone	HG10393-M

PGD / Phosphogluconate dehydrogenase Related Areas

Enzyme>>Carbohydrate Metabolism Enzymes>> PGD / Phosphogluconate dehydrogenase

PGD / Phosphogluconate dehydrogenase Alternative Names

PGD, Phosphogluconate dehydrogenase, 6PGD [Homo sapiens]

PGD, Phosphogluconate dehydrogenase, Pgd, RP23-249G3.4, 0610042A05Rik, AU019875, C78335 [Mus musculus]

PGD / Phosphogluconate dehydrogenase Background

Phosphogluconate dehydrogenase (PGD), also known as 6-PGD, 6PGDH, is an oxidative carboxylase that catalyses the decarboxylating reduction of 6-phosphogluconate into ribulose 5-phosphate in the presence of NADP. 6-PGD protein was absent from the oxidase complex isolated from B lymphocytes, suggesting a specific interaction with the neutrophil NADPH oxidase. PGD/6PGDH constitutes the pentose phosphate pathway and produces NADPH. 6PGDH is also considered as a lipogenic gene since NADPH is a pivotal cofactor for lipogenesis. 6PGDH mRNA is highly expressed in white adipose tissue and tightly modulated by nutritional status. Furthermore, ADD1/SREBP1c mediates insulin-dependent 6PGDH expression and that PI3-kinase is an important linker for its regulation.

PGD / Phosphogluconate dehydrogenase Related Studies

1. Baillet A, et al. (2011) Coupling of 6-phosphogluconate dehydrogenase with NADPH oxidase in neutrophils: Nox2 activity regulation by NADPH availability. FASEB J. 25(7): 2333-43.
2. Rho HK, et al. (2005) Transcriptional regulation of mouse 6-phosphogluconate dehydrogenase by ADD1/SREBP1c. Biochem Biophys Res Commun. 332(1): 288-96.
3. Broedel SE, et al. (1990). Genetic tagging, cloning, and DNA sequence of the Synechococcus sp. strain PCC 7942 gene (gnd) encoding 6-phosphogluconate dehydrogenase. J Bacteriol. 172 (7): 4023-31.
4. Adams MJ, et al. (1983). The three dimensional structure of sheep liver 6-phosphogluconate dehydrogenase at 2.6 A resolution. EMBO J. 2 (6): 1009-14.