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PGA4/Pepsinogen A Protein, Antibody, ELISA Kit, cDNA Clone

PGA4/Pepsinogen A Related Areas

PGA4/Pepsinogen A Related Pathways

PGA4/Pepsinogen A Related Product

    PGA4/Pepsinogen A Summary & Protein Information

    PGA4/Pepsinogen A Background

    Catalytic activity: Preferential cleavage: hydrophobic, preferably aromatic, residues in P1 and P1' positions. Cleaves 1-Phe-|-Val-2, 4-Gln-|-His-5, 13-Glu-|-Ala-14, 14-Ala-|-Leu-15, 15-Leu-|-Tyr-16, 16-Tyr-|-Leu-17, 23-Gly-|-Phe-24, 24-Phe-|-Phe-25 and 25-Phe-|- Tyr-26 bonds in the B chain of insulin.
    Subcellular location: Secreted.
    Sequence similarity: Belongs to the peptidase A1 family.C
    General information above from UniProt

    PGA4 (Pepsinogen 4, group I), or Pepsinogen A, is a member of the peptidase A1 family. Pepsin is expressed as a pro-form zymogen, pepsinogen, whose primary structure has an additional 44 amino acids. Pepsin is stored as pepsinogen so it will only be released when needed, and does not digest the body's own proteins in the stomach's lining. Five types of zymogens of pepsins, gastric digestive proteinases, are known: pepsinogens A, B, and F, progastricsin, and prochymosin. There are two major groups of pepsinogen, namely pepsinogen A (PGA) and pepsinogen C (PGC) (or progastricsin), and each frequently has isozymogens. The PGA3, PGA4 and PGA5 genes encode identical human pepsinogen A enzymes.

    PGA4/Pepsinogen A Alternative Name

    Pepsinogen A,PGA4,PGA5,FLJ58952,FLJ77962,PGA3, [human]

    PGA4/Pepsinogen A Related Studies

  • Kageyama T. (2002) Pepsinogens, progastricsins, and prochymosins: structure, function, evolution, and development. Cell Mol Life Sci. 59(2): 288-306.
  • Takahashi K. (1992) Gene structures of pepsinogens A and C. Scand J Clin Lab Invest Suppl. 210: 97-110.
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