All PEDF reagents are produced in house and quality controlled, including 10 PEDF Antibody, 36 PEDF Gene, 1 PEDF IPKit, 3 PEDF Lysate, 3 PEDF Protein, 3 PEDF qPCR. All PEDF reagents are ready to use.
Recombinant PEDF proteins are expressed by HEK293 Cells with fusion tags as C-His.
PEDFantibodies are validated with different applications, which are WB, ELISA, IHC-P, IP.
PEDFcDNA clones are full length sequence confirmed and expression validated. There are 13 kinds of tags for each PEDF of different species, especially GFP tag, OFP tag, FLAG tag and so on. There are three kinds of vectors for choice, cloning vector, expression vector and lentivrial expression vector.
Pigment epithelium-derived factor, also known as PEDF, Serpin F1, and SERPINF1, is a multiple functional protein which has both anti-angiogenic activity and neurotrophic activity at the same time. PEDF is a secreted glycoprotein that belongs to the noninhibitory serpin. It has an alpha/beta core serine-protease inhibitor domain, three major beta-sheets, and ten alpha-helices. PEDF does not inhibit either serine or cysteine proteinases. PEDF exerts diverse physiological activities including anti-angiogenesis, anti-vasopermeability, anti-tumor, and neurotrophic activities. PEDF acts via multiple high affinity ligands and cell receptors. It has been described as a natural angiogenesis inhibitor with neurotrophic and immune-modulation properties. PEDF induces macrophages apoptosis and necrosis through the activation of peroxisome proliferator-activated receptor-gamma by which PEDF could modulate inflammatory reactions in septic shock. It balances angiogenesis in the eye and blocks tumor progression.