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PEDF  Protein, Antibody, ELISA Kit, cDNA Clone

Expression host: Human Cells  
50 µg 
20 µg 
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Expression host: Human Cells  
50 µg 
20 µg 
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Expression host: Human Cells  
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20 µg 
100 µg 
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PEDF Related Area

PEDF Related Pathways

    PEDF Summary & Protein Information

    PEDF Background

    Gene Summary: The protein encoded by this SERPINF1 gene is a member of the serpin family, although it does not display the serine protease inhibitory activity shown by many of the other serpin family members. SerpinF1 is secreted and strongly inhibits angiogenesis. In addition, SerpinF1 is a neurotrophic factor involved in neuronal differentiation in retinoblastoma cells.[provided by RefSeq, Mar 2011]
    General information above from NCBI
    Domain: The N-terminal (AA 44-121) exhibits neurite outgrowth-inducing activity. The C-terminal exposed loop (AA 382-418) is essential for serpin activity.
    Subcellular location: Secreted {ECO:0000269|PubMed:17081065}. Melanosome {ECO:0000269|PubMed:17081065}. Note=Enriched in stage I melanosomes.
    Tissue specificity: Retinal pigment epithelial cells and blood plasma. {ECO:0000269|PubMed:12737624}.
    Developmental stage: Expressed in quiescent cells.
    Post-translational: The N-terminus is blocked. Extracellular phosphorylation enhances antiangiogenic activity. {ECO:0000269|PubMed:15374885}.; N- and O-glycosylated. O-glycosylated with a core 1 or possibly core 8 glycan. {ECO:0000269|PubMed:11562499, ECO:0000269|PubMed:16335952, ECO:0000269|PubMed:19139490, ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:19838169}.
    Involvement in disease: DISEASE: Osteogenesis imperfecta 6 (OI6) [MIM:613982]: A form of osteogenesis imperfecta, a connective tissue disorder characterized by low bone mass, bone fragility and susceptibility to fractures after minimal trauma. Disease severity ranges from very mild forms without fractures to intrauterine fractures and perinatal lethality. Extraskeletal manifestations, which affect a variable number of patients, are dentinogenesis imperfecta, hearing loss, and blue sclerae. OI6 is a severe, autosomal recessive form compatible with OI type III in the Sillence classification. {ECO:0000269|PubMed:21353196}. Note=The disease is caused by mutations affecting the gene represented in this entry.
    Sequence similarity: Belongs to the serpin family. {ECO:0000305}.
    General information above from UniProt

    Pigment epithelium-derived factor, also known as PEDF, Serpin F1, and SERPINF1, is a multiple functional protein which has both anti-angiogenic activity and neurotrophic activity at the same time. PEDF is a secreted glycoprotein that belongs to the noninhibitory serpin. It has an alpha/beta core serine-protease inhibitor domain, three major beta-sheets, and ten alpha-helices. PEDF does not inhibit either serine or cysteine proteinases. PEDF exerts diverse physiological activities including anti-angiogenesis, anti-vasopermeability, anti-tumor, and neurotrophic activities. PEDF acts via multiple high affinity ligands and cell receptors. It has been described as a natural angiogenesis inhibitor with neurotrophic and immune-modulation properties. PEDF induces macrophages apoptosis and necrosis through the activation of peroxisome proliferator-activated receptor-gamma by which PEDF could modulate inflammatory reactions in septic shock. It balances angiogenesis in the eye and blocks tumor progression.

    PEDF Alternative Name

    OI6,OI12,PEDF,EPC-1,PIG35, [homo-sapiens]
    EPC-1,PEDF,PIG35,SERPINF1, [human]
    AI195227,EPC-1,Pedf,Pedfl,RP23-384C18.1,Sdf3,Serpinf1, [mouse]
    Pedf,Sdf3,EPC-1,Pedfl,AI195227, [mus-musculus]

    PEDF Related Studies

  • Ren, JG. et al., 2005, Med Hypotheses. 64 (1): 74-8.
  • Filleur, S. et al., 2009. J Cell Biochem. 106 (5): 769-75.
  • Kawaguchi, T. et al., 2010, Curr Mol Med. 10 (3): 302-11.
  • Yamagishi, SI. et al., 2010, Curr Mol Med. 10 (3): 284-91.
  • Nakamura, T. et al., 2010, Curr Mol Med. 10 (3): 312-6.