PDK1

PDK1 inhibits the mitochondrial pyruvate dehydrogenase complex by phosphorylation of the E1 alpha subunit, thus contributing to the regulation of glucose metabolism.

PDK1 Related Areas

Enzyme>>Protein Kinase>>Intracellular Kinase>>PDK-1

Signal Transduction>>Protein Kinase>>Intracellular Kinase>>PDK-1

PDK1 Alternative Names

PDK-1, PDK1, OTTHUMP00000205076; OTTHUMP00000205082 [Homo sapiens]

Pdk1, RP23-5K9.5, B830012B01, D530020C15Rik [Mus musculus]

Summaries for PDK1

Entrez Gene summary for PDK1:

Pyruvate dehydrogenase (PDH) is a mitochondrial multienzyme complex that catalyzes the oxidative decarboxylation of pyruvate and is one of the major enzymes responsible for the regulation of homeostasis of carbohydrate fuels in mammals. The enzymatic activity is regulated by a phosphorylation/dephosphorylation cycle. Phosphorylation of PDH by a specific pyruvate dehydrogenase kinase (PDK) results in inactivation. [provided by RefSeq, Jul 2008]

Wikipedia summary for PDK1:

Pyruvate dehydrogenase lipoamide kinase isozyme 1, mitochondrial is an enzyme that in humans is encoded by the PDK1 gene.[1][2] It codes for an isozyme of pyruvate dehydrogenase kinase (PDK).

Human PDK1 Protein General Information

 

• Protein names: Pyruvate dehydrogenase kinase isoform 1
• Sequence length: 436 AA.
• Catalytic activity: ATP + [pyruvate dehydrogenase (acetyl-transferring)] = ADP + [pyruvate dehydrogenase (acetyl-transferring)] phosphate.
• Sequence similarities: PDK1 belongs to the PDK/BCKDK protein kinase family. PDK1 contains 1 histidine kinase domain.
• Enzyme regulation: PDK1 is inhibited by AZD7545, dichloroacetate and radicicol.
• Subcellular location: Mitochondrion matrix.
• Tissue specificity: PDK1 is expressed predominantly in the heart.

General information above from UniProt

Function for PDK1 Protein

UniProtKB:

PDK1 inhibits the mitochondrial pyruvate dehydrogenase complex by phosphorylation of the E1 alpha subunit, thus contributing to the regulation of glucose metabolism.

Genatlas:

• phosphorylating PDH and resulting in its inactivation and thus contributing to the regulation of glucose metabolism
• PDK1 plays an important role in maintaining glycolysis
• PDK1 activates a group of kinases, including AKT1, p70 ribosomal S6 kinase (S6K), and serum and glucocorticoid-induced protein kinase (SGK), that mediate many of the effects of insulin as well as other agonists
• essential role of PDK1 in cardiovascular development through activation of AKT1 and SNAI1
• PDK1 plays an indispensable role in the development of the cardiovascular system

Homology for human PDK1

• ortholog to murine Pdk1
• ortholog to rattus Pdk1