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>Human Cell Expressed
>Rat PDGFRB / PDGFR-1 Protein (His Tag) (Receptor Tyrosine Kinase)
|Catalog||Size (Price)||Quantity||In Stock||Operation|
Platelet derived growth factor receptor, beta polypeptide Protein Datasheet
PDGFRB / PDGFR-1 Protein Price Inquiry ( Available Sizes )
- ≥1mg Bulk: Inquiring Price
PDGFRB / PDGFR-1 Protein Product Information
PDGFRB, Pdgfr, Pdgfr1
A DNA sequence encoding the rat PDGFRB(Q05030)(Met1-Lys530) was expressed, fused with a polyhistidine tag at the C-terminus.
|Expression Host:||Human Cells|
PDGFRB / PDGFR-1 Protein QC Testing
|Purity:||> 95 % as determined by SDS-PAGE||SDS-PAGE:
PDGFRB / PDGFR-1 protein
|Endotoxin:||< 1.0 EU per μg of the protein as determined by the LAL method|
|Stability:||Samples are stable for up to twelve months from date of receipt at -70℃|
|Predicted N terminal:||Leu 32|
The recombinant rat PDGFRB comprises 510 amino acids and predicts a molecular mass of 57.6 kDa. The apparent molecular mass of the recombinant protein is approximately 92 kDa in SDS-PAGE under reducing conditions due to glycosylation.
|Formulation:||Lyophilized from sterile PBS, pH7.4.
PDGFRB / PDGFR-1 Protein Usage Guide
|Storage:||Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.|
|Reconstitution:||A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.|
PDGFRB / PDGFR-1 Protein Related Products & Topics
|Molecule||Species||Description //For Detailed Info. and Price------CLICK!||Cat. No|
|PDGFRB/CD140b||Human||PDGFRB/CD140b Protein, Recombinant||10514-H03H|
|PDGFRB/CD140b||Human||PDGFRB/CD140b Protein, Recombinant||10514-H08H|
|PDGFRB||Rat||PDGFRB / PDGFR-1 Protein, Recombinant||80347-R08H|
|Molecule||Application||Description //For Detailed Info. and Price------CLICK!||Cat. No|
|ELISA||PDGFRB / CD140b Antibody||10514-MM10|
|ELISA||Mouse Monoclonal Antibody||10514-MM11|
|ELISA||PDGFRB / CD140b Antibody||10514-MM12|
|WB, ELISA||Rabbit Polyclonal Antibody||10514-RP01|
|WB, ELISA||Rabbit Polyclonal Antibody (Antigen Affinity Purified)||10514-RP02|
PDGFRB / PDGFR-1 Protein Description
Beta-type platelet-derived growth factor receptor, also known as CD140b, PDGFRB, PDGF-R-beta, PDGF receptor-β, is a member of the protein kinase superfamily and CSF-1/PDGF receptor subfamily. The PDGF family consists of PDGF-A, -B, -C and -D, which form either homo- or heterodimers (PDGF-AA, -AB, -BB, -CC, -DD). The four PDGFs are inactive in their monomeric forms. The PDGFs bind to the protein tyrosine kinase receptors PDGF receptor-α and -β. These two receptor isoforms dimerize upon binding the PDGF dimer, leading to three possible receptor combinations, namely -αα, -ββ and -αβ. The extracellular region of the PDGF receptor-β consists of five immunoglobulin-like domains while the intracellular part is a tyrosine kinase domain. The ligand-binding sites of PDGF receptor-α and -β are located to the three first immunoglobulin-like domains. PDGF-CC specifically interacts with PDGFR-αα and -αβ, but not with –ββ, and thereby resembles PDGF-AB. PDGF-DD binds to PDGFR-ββ with high affinity, and to PDGFR-αβ to a much lower extent and is regarded as PDGFR-ββ specific. PDGF-AA binds only to PDGFR-αα, while PDGF-BB is the only PDGF that can bind all three receptor combinations with high affinity.
- Chi, KD. et al., 1997, Oncogene 15: 1051-7.
- Arcaro, A. et al., 2000, Mol. Cell. Biol. 20: 3817-30.
- Bergsten, E. et al., 2001, Nat. Cell Biol. 3: 512-16.
- Zhang, Z. et al., 2004, Protein Sci. 13: 2819-24.
- Morerio, C. et al., 2004, Cancer Res. 64: 2649-51.