Anti-PDGFRB Antibody

Cat: 10514-MM10
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All PDGFRB Reagents
Anti-PDGFRB Antibody (Mouse Monoclonal antibody) General Information
Product name
Anti-PDGFRB Antibody
Validated applications
IHC-P
Species reactivity
Reacts with: Human
Specificity
Human PDGFRB
Immunogen
Recombinant Human PDGFRB / CD140b protein (Catalog#10514-H08H)
Preparation
This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human PDGFRB / CD140b (rh PDGFRB / CD140b; Catalog#10514-H08H; NP_002600.1; Met 1-Lys 531). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography.
Source
Monoclonal Mouse IgG2a Clone #4D5D6
Purification
Protein A
Formulation
0.2 μm filtered solution in PBS with 5% trehalose
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-PDGFRB Antibody (Mouse Monoclonal antibody) Validated Applications
Application Dilution Notes
IHC-P 10-30 μg/mL  

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-PDGFRB Antibody (Mouse Monoclonal antibody) Images
Human PDGFRB/CD140b Immunohistochemistry(IHC) 3794
Immunochemical staining of human PDGFRb in human mammary adenocarcinoma with mouse monoclonal antibody (15 µg/mL, formalin-fixed paraffin embedded sections). Positive staining was localized to blood vessel endothelium.
Human PDGFRB/CD140b Immunohistochemistry(IHC) 3795
Immunochemical staining of human PDGFRb in human liver with mouse monoclonal antibody (15 µg/mL, formalin-fixed paraffin embedded sections). Positive staining was localized to blood vessel endothelium.
Human PDGFRB/CD140b Immunohistochemistry(IHC) 3797
Immunochemical staining of human PDGFRb in human brain with mouse monoclonal antibody (15 µg/mL, formalin-fixed paraffin embedded sections). Positive staining was localized to blood vessel endothelium.
Anti-PDGFRB Antibody Alternative Names
Anti-CD140B Antibody;Anti-IBGC4 Antibody;Anti-IMF1 Antibody;Anti-JTK12 Antibody;Anti-KOGS Antibody;Anti-PDGFR Antibody;Anti-PDGFR-1 Antibody;Anti-PDGFR1 Antibody;Anti-PENTT Antibody
PDGFRB Background Information

The cluster of differentiation (CD) system is commonly used as cell markers in immunophynotyping. Different kinds of cells in the immune system can be identified through the surface CD molecules which associating with the immune function of the cell. There are more than 320 CD unique clusters and subclusters have been identified. Some of the CD molecules serve as receptors or ligands important to the cell through initiating a signal cascade which then alter the behavior of the cell. Some CD proteins do not take part in cell signal process but have other functions such as cell adhesion. CD140b, also known as PDGFRB, is a member of the CD system. CD140b is a cell surface tyrosine kinase receptor essencial for development interacting with the platelet-derived growth factors (PDGFs) which serves as mitogens for mesenchymal cells. CD140b can bind with platelet-derived growth factor (PDGF)-B, that are secreted by tumors and phosphorylation of PDGFR-β was correlated with depth of cancer invasion at statistically significant level.

Immune Checkpoint   Immunotherapy   Cancer Immunotherapy   Targeted Therapy

Full Name
platelet-derived growth factor receptor, beta polypeptide
References
  • Zola H, et al. (2007) CD molecules 2006-human cell differentiation molecules. J Immunol Methods. 318 (1-2): 1-5.
  • Ho IC, et al. (2009) GATA3 and the T-cell lineage: essential functions before and after T-helper-2-cell differentiation. Nat Rev Immunol. 9 (2): 125-35.
  • Matesanz-Isabel J, et al. (2011) New B-cell CD molecules. Immunology Letters.134 (2): 104-12.
  • Suzuki S, et al. (2010) Clinicopathological significance of platelet-derived growth factor (PDGF)-B and vascular endothelial growth factor-A expression, PDGF receptor- phosphorylation, and microvessel density in gastric cancer. BMC cancer. 10: 659.
  • Product Description Host Clonality Application Catalog# (PDF)
    Anti-PDGFRB Antibody Rabbit Polyclonal ELISA,IHC-P 90215-T24
    Anti-PDGFRB Antibody Rabbit Polyclonal ELISA 90215-RP01
    Anti-PDGFRB Antibody Mouse Monoclonal ELISA(Det) 10514-MM08
    Anti-PDGFRB Antibody (FITC) Mouse Monoclonal FCM 10514-MM11-F
    Anti-PDGFRB Antibody Rabbit Monoclonal FCM 10514-R206
    Anti-PDGFRB Antibody (FITC) Rabbit Monoclonal FCM 10514-R206-F
    Anti-PDGFRB Antibody Mouse Monoclonal IHC-P 10514-MM12
    Anti-PDGFRB Antibody Mouse Monoclonal ELISA(Cap) 10514-MM06
    Anti-PDGFRB Antibody Rabbit Polyclonal ELISA 10514-RP02
    Anti-PDGFRB Antibody (APC) Rabbit Monoclonal FCM 10514-R206-A
    Anti-PDGFRB Antibody (APC) Mouse Monoclonal FCM 10514-MM11-A
    Anti-PDGFRB Antibody (PE) Rabbit Monoclonal FCM 10514-R206-P
    Anti-PDGFRB Antibody Rabbit Monoclonal ELISA 10514-R213
    Anti-PDGFRB Antibody (PE) Mouse Monoclonal FCM 10514-MM11-P
    Anti-PDGFRB Antibody Mouse Monoclonal ELISA,FCM 10514-MM11
    Anti-PDGFRB Antibody Rabbit Polyclonal ELISA 10514-RP01
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