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PDGFRB/CD140b Mouse MAb

  • PDGFRB / CD140b Antibody, Mouse MAb, Immunohistochemistry
  • PDGFRB / CD140b Antibody, Mouse MAb, Immunohistochemistry
  • PDGFRB / CD140b Antibody, Mouse MAb, Immunohistochemistry
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Human PDGFRB Antibody Product Information
Immunogen:Recombinant Human PDGFRB / CD140b protein (Catalog#10514-H08H)
Clone ID:4D5D6
Ig Type:Mouse IgG2a
Concentration:
Endotoxin:
Formulation:0.2 μm filtered solution in PBS with 5% trehalose
Preparation:This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human PDGFRB / CD140b (rh PDGFRB / CD140b; Catalog#10514-H08H; NP_002600.1; Met 1-Lys 531). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography.
Human PDGFRB Antibody IHC Application Image
PDGFRB / CD140b Antibody, Mouse MAb, Immunohistochemistry
[Click to enlarge image]
Caption:
Immunochemical staining of human PDGFRb in human brain with mouse monoclonal antibody (15 µg/mL, formalin-fixed paraffin embedded sections). Positive staining was localized to blood vessel endothelium.
PDGFRB / CD140b Antibody, Mouse MAb, Immunohistochemistry
[Click to enlarge image]
Caption:
Immunochemical staining of human PDGFRb in human liver with mouse monoclonal antibody (15 µg/mL, formalin-fixed paraffin embedded sections). Positive staining was localized to blood vessel endothelium.
PDGFRB / CD140b Antibody, Mouse MAb, Immunohistochemistry
[Click to enlarge image]
Caption:
Immunochemical staining of human PDGFRb in human mammary adenocarcinoma with mouse monoclonal antibody (15 µg/mL, formalin-fixed paraffin embedded sections). Positive staining was localized to blood vessel endothelium.
Other PDGFRB Antibody Products
PDGFRB/CD140b Background

The cluster of differentiation (CD) system is commonly used as cell markers in immunophynotyping. Different kinds of cells in the immune system can be identified through the surface CD molecules which associating with the immune function of the cell. There are more than 320 CD unique clusters and subclusters have been identified. Some of the CD molecules serve as receptors or ligands important to the cell through initiating a signal cascade which then alter the behavior of the cell. Some CD proteins do not take part in cell signal process but have other functions such as cell adhesion. CD140b, also known as PDGFRB, is a member of the CD system. CD140b is a cell surface tyrosine kinase receptor essencial for development interacting with the platelet-derived growth factors (PDGFs) which serves as mitogens for mesenchymal cells. CD140b can bind with platelet-derived growth factor (PDGF)-B, that are secreted by tumors and phosphorylation of PDGFR-β was correlated with depth of cancer invasion at statistically significant level.

Immune Checkpoint   Immunotherapy   Cancer Immunotherapy   Targeted Therapy

Human PDGFRB/CD140b References
  • Zola H, et al. (2007) CD molecules 2006-human cell differentiation molecules. J Immunol Methods. 318 (1-2): 1-5.
  • Ho IC, et al. (2009) GATA3 and the T-cell lineage: essential functions before and after T-helper-2-cell differentiation. Nat Rev Immunol. 9 (2): 125-35.
  • Matesanz-Isabel J, et al. (2011) New B-cell CD molecules. Immunology Letters.134 (2): 104-12.
  • Suzuki S, et al. (2010) Clinicopathological significance of platelet-derived growth factor (PDGF)-B and vascular endothelial growth factor-A expression, PDGF receptor- phosphorylation, and microvessel density in gastric cancer. BMC cancer. 10: 659.
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