PDGFRA Protein & Antibody (CD140a)

Platelet-Derived Growth Factor Receptor Alpha (Cluster of Differentiation 140a)

PDGFRA Products

PDGFRA Protein, Recombinant

Molecule	Species	Description //For Detailed Info. and Price------CLICK!	Cat. No
PDGFRA/CD140a	Human	PDGFRA/CD140a/Fc Protein, Recombinant	10556-H02H
PDGFRA/CD140a	Human	PDGFRA/CD140a Protein, Recombinant	10556-H08H
PDGFRA/CD140a	Human	PDGFRa / CD140a Protein, Recombinant, with GST Tag	10556-H20B1
PDGFRA/CD140a	Human	PDGFRA/CD140a Protein, Recombinant	10556-HCCH

PDGFRA Antibody

Molecule	Application	Description //For Detailed Info. and Price------CLICK!	Cat. No
Human PDGFRA/CD140a	ELISA	Mouse Monoclonal Antibody	10556-MM03
Human PDGFRA/CD140a	WB	PDGFRA / CD140a Antibody	10556-MM14
Human PDGFRA/CD140a	WB, ELISA	Rabbit Monoclonal Antibody	10556-R065
Human PDGFRA/CD140a	WB, ELISA	Rabbit Polyclonal Antibody	10556-RP01
Human PDGFRA/CD140a	WB, ELISA	Rabbit Polyclonal Antibody (Antigen Affinity Purified)	10556-RP02

PDGFRA Elisa Pair Set

Molecule	Application	Description //For Detailed Info. and Price------CLICK!	Cat. No
Human PDGFRA/CD140a	ELISA	PDGFRA Elisa Pair Set	SEK10556

PDGFRA cDNA Clone

Molecule	Species	Description //For Detailed Info. and Price------CLICK!	Cat. No
PDGFRA/CD140a	Human	Homo sapiens PDGFRA/CD140a cDNA Clone(NM_006206.4)	HG10556-M
PDGFRA/CD140a	Human	Human PDGFRα ORF Expression Clone, FLAG-tagged	HG10556-M-F
PDGFRA/CD140a	Human	Human PDGFRα ORF Expression Clone, HA-tagged	HG10556-M-Y
PDGFRA/CD140a	Rat	Rat PDGFRA Gene cDNA Clone / ORF Clone	RG80433-G

PDGFRA Alternative Names

PDGFRA , CD140A, MGC74795, PDGFR2, RHEPDGFRA [Homo sapiens]

Pdgfra , AI115593, CD140a, Pdgfr-2 [Mus musculus]

PDGFRA Related Areas

Cardiovascular>>Platelet>>PDGFRA/CD140a

Enzyme>>Protein Kinase>>Receptor Tyrosine Kinase>>PDGFRA/CD140a

Signal Transduction>>Protein Kinase>>Receptor Tyrosine Kinase>>PDGFRA/CD140a

Stem Cell>>Neural Stem Cell (NSC)>>Neural Stem Cell Markers>>PDGFRA/CD140a

Stem Cell>>Neural Stem Cell (NSC)>>Glial Cell Markers>>PDGFRA/CD140a

Cancer>>Growth factor & Receptor>>PDGF & Receptor>>PDGFRA/CD140a

Cancer>>Growth factor & Receptor>>Receptor Tyrosine Kinase>>PDGFRA/CD140a

Immunology>>Cluster of Differentiation>>Other>>PDGFRA/CD140a

PDGFRA Background

PDGFRA, also known as CD140a, together with the structurally homolog protein PDGFRB (CD140b), are cell surface receptors for members of the platelet-derived growth factor family. They are members of the class III subfamily of receptor tyrosine kinase (RTKs) with the similar structure characteristics of five immunoglobulin-like domains in their extracellular region and a split kinase domain in their intracellular region. PDGFRA is expressed in oligodendrocyte progenitor cells and mesothelial cell, and binds all three ligand isoforms PDGF-AA, PDGF-BB and PDGF-AB with high affinity, whereas PDGFRB dose not bind PDGF-AA. PDGFRA plays an essential role in regulating proliferation, chemotaxis and migration of mesangial cells. Recent studies have indicated that PDGFRA acts as a critical mediator of signaling in testis organogenesis and Leydig cell differentiation, and in addition, particularly important for kidney development. Additionally, PDGFRA is involved in tumor angiogenesis and maintenance of the tumor microenvironment and has been implicated in development and metastasis of Hepatocellular carcinoma (HCC). PDGFRA may represent a potential therapeutic target in thymic tumours. PDGFRA gene amplification rather than gene mutation may be the underlying genetic mechanism driving PDGFRA overexpression in a portion of gliomas.

PDGFRA Related Studies

1. Oseini AM, et al. (2009) PDGFRalpha: a new therapeutic target in the treatment of hepatocellular carcinoma? Expert Opin Ther Targets. 13(4): 443-54.
2. Meister M, et al. (2009) Expression and mutational status of PDGFR in thymic tumours. Anticancer Res. 29(10): 4057-61.
3. Martinho O, et al. (2009) Expression, mutation and copy number analysis of platelet-derived growth factor receptor A (PDGFRA) and its ligand PDGFA in gliomas. Br J Cancer. 101(6): 973-82.