Anti-PDGFRA Antibody

Cat: 10556-RP02
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Anti-PDGFRA Antibody (Rabbit Polyclonal antibody) General Information
Product name
Anti-PDGFRA Antibody
Validated applications
ELISA
Species reactivity
Reacts with: Human
Specificity
Human PDGFRA
Immunogen
Recombinant Human PDGFRa / CD140a protein (Catalog#10556-H08H)
Preparation
Produced in rabbits immunized with purified, recombinant Human PDGFRa / CD140a (rhPDGFRa; Catalog#10556-H08H; NP_006197.1; Met 1-Glu 524). PDGFRa specific IgG was purified by human PDGFRa affinity chromatography .
Source
Polyclonal Rabbit IgG
Purification
Protein A & Antigen Affinity
Formulation
0.2 μm filtered solution in PBS
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-PDGFRA Antibody (Rabbit Polyclonal antibody) Validated Applications
Application Dilution Notes
ELISA 1:1000-1:2000  

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-PDGFRA Antibody Alternative Names
Anti-CD140A Antibody;Anti-PDGFR-2 Antibody;Anti-PDGFR2 Antibody;Anti-RHEPDGFRA Antibody
PDGFRA Background Information

PDGFRA, also known as CD140a, together with the structurally homolog protein PDGFRB (CD140b), are cell surface receptors for members of the platelet-derived growth factor family. They are members of the class III subfamily of receptor tyrosine kinase (RTKs) with the similar structure characteristics of five immunoglobulin-like domains in their extracellular region and a split kinase domain in their intracellular region. PDGFRA is expressed in oligodendrocyte progenitor cells and mesothelial cell, and binds all three ligand isoforms PDGF-AA, PDGF-BB and PDGF-AB with high affinity, whereas PDGFRB dose not bind PDGF-AA. PDGFRA plays an essential role in regulating proliferation, chemotaxis and migration of mesangial cells. Recent studies have indicated that PDGFRA acts as a critical mediator of signaling in testis organogenesis and Leydig cell differentiation, and in addition, particularly important for kidney development. Additionally, PDGFRA is involved in tumor angiogenesis and maintenance of the tumor microenvironment and has been implicated in development and metastasis of Hepatocellular carcinoma (HCC). PDGFRA may represent a potential therapeutic target in thymic tumours. PDGFRA gene amplification rather than gene mutation may be the underlying genetic mechanism driving PDGFRA overexpression in a portion of gliomas.

Immune Checkpoint   Immunotherapy   Cancer Immunotherapy   Targeted Therapy

Full Name
platelet-derived growth factor receptor, alpha polypeptide
References
  • Oseini AM, et al. (2009) PDGFRalpha: a new therapeutic target in the treatment of hepatocellular carcinoma? Expert Opin Ther Targets. 13(4): 443-54.
  • Meister M, et al. (2009) Expression and mutational status of PDGFR in thymic tumours. Anticancer Res. 29(10): 4057-61.
  • Martinho O, et al. (2009) Expression, mutation and copy number analysis of platelet-derived growth factor receptor A (PDGFRA) and its ligand PDGFA in gliomas. Br J Cancer. 101(6): 973-82.
  • Product Description Host Clonality Application Catalog# (PDF)
    Anti-PDGFRA Antibody Rabbit Polyclonal ELISA 80433-T16
    Anti-PDGFRA Antibody Rabbit Polyclonal ELISA 80433-RP01
    Anti-PDGFRA Antibody Mouse Monoclonal ELISA,ELISA(Cap) 10556-MM07
    Anti-PDGFRA Antibody (FITC) Mouse Monoclonal FCM 10556-MM02-F
    Anti-PDGFRA Antibody (PE) Mouse Monoclonal FCM 10556-MM02-P
    Anti-PDGFRA Antibody (APC) Mouse Monoclonal FCM 10556-MM02-A
    Anti-PDGFRA Antibody Rabbit Polyclonal ELISA 10556-RP01
    Anti-PDGFRA Antibody Rabbit Monoclonal ELISA 10556-R065
    Anti-PDGFRA Antibody Mouse Monoclonal ELISA 10556-MM03
    Anti-PDGFRA Antibody Mouse Monoclonal WB 10556-MM14
    Anti-PDGFRA Antibody Mouse Monoclonal ELISA,FCM 10556-MM02
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