Platelet-Derived Growth Factor (PDGF) & Receptor

Sino biological offers a comprehensive set of tools for platelet-derived growth factor (PDGF) related research, including recombinant proteins, antibodies (rabbit mAbs, mouse mAbs, rabbit pAbs), ELISA kits, and ORF cDNA clones. Platelet-derived growth factors (PDGFs) constitute a group of growth factors that play a significant role in blood vessel formation, and the growth of blood vessels from already existing blood vessel tissue. Platelet-derived growth factor (PDGF) is mainly believed to be an important mitogen for connective tissue, especially for fibroblasts that serve in wound healing. However, PDGF also has important roles in embryonic development, cell proliferation, cell migration, and angiogenesis. Like many other growth factors that have been linked to disease, platelet-derived growth factor has provided a market for protein receptor antagonists to treat disease.

Platelet-Derived Growth Factor (PDGF) & Receptor Products

• PDGF-A
• PDGF-C
• PDGFRA / CD140a
• PDGF-B
• PDGF-D
• PDGFRB / CD140b

Platelet-Derived Growth Factor (PDGF) & Receptor Background

Platelet-derived growth factors (PDGFs) constitute a group of growth factors that play a significant role in blood vessel formation (angiogenesis), and the growth of blood vessels from already existing blood vessel tissue. There are five different isoforms of PDGF, including PDGF-A, PDGF-B, PDGF-C, PDGF-D and an AB heterodimer PDGF-AB. Platelet-derived growth factor acts through a cell surface receptor, PDGFR, which is a receptor tyrosine kinase. Two types of PDGFRs have been identified: alpha type (PDGFRA) and beta type (PDGFRB) PDGFRs. The alpha type binds to PDGF-AA, PDGF-BB and PDGF-AB while the beta type PDGFR binds with high affinity to PDGF-BB and PDGF-AB. Upon activation by PDGF, PDGFR dimerise and activate signaling pathway involving gene expression, cell cycle and many other processes. Platelet-derived growth factor (PDGF) is mainly believed to be an important mitogen for connective tissue, especially for fibroblasts that serve in wound healing. However, PDGF also has important roles in embryonic development, cell proliferation, cell migration, and angiogenesis. Like many other growth factors that have been linked to disease, platelet-derived growth factor has provided a market for protein receptor antagonists to treat disease.

Platelet-Derived Growth Factor (PDGF) & Receptor Related Studies

1. Matsui T, et al. (1989) Isolation of a novel receptor cDNA establishes the existence of two PDGF receptor genes. Science 243(4892): 800–4.
2. Heidaran MA, et al. (1991) Role of alpha beta receptor heterodimer formation in beta platelet-derived growth factor (PDGF) receptor activation by PDGF-AB. J. Biol. Chem. 266(30): 20232–7.
3. Nobuo Jo, et al. (2006) Inhibition of platelet-derived growth factor B signaling enhances the efficacy of anti-vascular endothelial growth factor therapy in multiple models of ocular neovascularization. American Journal of Pathology. 168:2036-53.
4. Ricardo H. et al. (2006) Biology of platelet-derived growth factor and its involvement in disease. Mayo Clinic Proceedings. 81(9): 1241-57.
5. PengF, et al. (2008) Mechanisms of platelet-derived growth factor-mediated neuroprotection--implications in HIV dementia. Eur J Neurosci. 28(7):1255-64.