PDGF-D Protein

Platelet Derived Growth Factor D

PDGF-D Products

PDGF-D Protein, Recombinant

Molecule	Species	Description	Cat. No
PDGF-D	Human	PDGF-D/Fc Protein, Recombinant	10281-H01H

PDGF-D cDNA Clone

Molecule	Species	Description	Cat. No
PDGF-D	Human	Homo sapiens PDGF-D transcript variant 1 cDNA Clone(NM_025208.4)	HG10281-M
PDGF-D	Human	PDGFD cDNA Clone / ORF Clone	HG13232-G
PDGF-D	Mouse	Mouse PDGF-D cDNA Clone / ORF Clone	MG50912-G

PDGF-D Alternative Names

PDGFD, IEGF, MGC26867, MSTP036, SCDGF-B, SCDGFB

PDGF-D Related Areas

Cardiovascular>>Platelet>>PDGF-D

Cancer>>Growth factor & Receptor>>PDGF & Receptor>>PDGF-D

PDGF-D Related Products

Protein Products

Molecule	Species	Description //For Detailed Info. and Price------CLICK!
PDGF-C	Human	PDGF-C/Fc Protein, Recombinant
PDGF-C	Mouse	PDGF-C Protein, Recombinant
PDGFRA/CD140a	Human	PDGFRA/Fc Protein, Recombinant
PDGFRA/CD140a	Human	PDGFRA Protein, Recombinant
PDGFRA/CD140a	Human	PDGFRA Protein, Recombinant
PDGFRB/CD140b	Human	PDGFRB/CD140b Protein, Recombinant
PDGFRB/CD140b	Human	PDGFRB Protein, Recombinant

Antibody Products

Molecule	Application	Description //For Detailed Info. and Price------CLICK!
Human PDGFRA/CD140a	ELISA	Mouse Monoclonal Antibody
Human PDGFRA/CD140a	WB, ELISA	Rabbit Polyclonal Antibody
Human PDGFRA/CD140a	WB, ELISA	Rabbit Polyclonal Antibody (Antigen Affinity Purified)
Human PDGFRB/CD140b	ELISA	Mouse Monoclonal Antibody
Human PDGFRB/CD140b	WB, ELISA	Rabbit Polyclonal Antibody
Human PDGFRB/CD140b	WB, ELISA	Rabbit Polyclonal Antibody (Antigen Affinity Purified)

cDNA Clone Products

Molecule	Species	Description //For Detailed Info. and Price------CLICK!
PDGF-A	Human	Human PDGF-A cDNA Clone / ORF Clone
PDGF-A	Mouse	Mus musculus PDGF-A cDNA Clone
PDGF-A	Rat	Rat PDGF-A cDNA Clone / ORF Clone
PDGF-B	Human	Homo sapiens PDGF-B cDNA Clone(NM_002608.2)
PDGF-B	Rat	Rattus norvegicus PDGF-B cDNA Clone
PDGF-C	Human	Homo sapiens PDGF-C cDNA Clone(NM_016205.1)
PDGF-C	Mouse	Mus musculus PDGF-C cDNA Clone
PDGFRA/CD140a	Human	Homo sapiens PDGFRA cDNA Clone(NM_006206.4)
PDGFRB/CD140b	Human	Homo sapiens PDGFRB cDNA Clone(NM_002609.3)

PDGF-D Background

Platelet-derived growth factor D (PDGF-D), also known as Iris-expressed growth factor, is a member of the PDGF/vascular endothelial growth factor family. The four members of this family are mitogenic factors for cells of mesenchymal origin and are characterized by a core motif of eight cysteines, seven of which are found in this factor. PDGF-D/PDGFD only forms homodimers and, therefore, does not dimerize with the other three family members. It differs from alpha and beta members of this family in having an unusual N-terminal domain, the CUB domain. The expression of PDGF-D/PDGFD in the eye is tissue-specific. In the anterior segment, it is localized to iris and ciliary body, whereas in the retina, PDGF-D/PDGFD is restricted to the outer plexiform layer. PDGF-D/PDGFD is present in aqueous humor but is not detectable in mature lens or in mouse lens-derived alphaTN4-1 cells. PDGF-D/PDGFD is highly expressed in human breast cancer and facilitates tumor growth and lymph node metastasis, making it a potential target in breast cancer. PDGF-D/PDGFD increases drug delivery and hence improves the efficacy of chemotherapy through vessel normalization. Intervention in the PDGF-D pathway in the eye, perhaps by antibody or blocking peptide, could be useful in the treatment of certain cataracts, including post-operative secondary cataract.

PDGF-D Related Studies

1. Ray S, et al. (2005) Platelet-derived growth factor D, tissue-specific expression in the eye, and a key role in control of lens epithelial cell proliferation. J Biol Chem. 280(9): 8494-502.
2. Uutela M, et al. (2004) PDGF-D induces macrophage recruitment, increased interstitial pressure, and blood vessel maturation during angiogenesis. Blood. 104 (10): 3198-204.
3. Taneda S, et al. (2004) Obstructive uropathy in mice and humans: potential role for PDGF-D in the progression of tubulointerstitial injury. J Am Soc Nephrol. 14 (10): 2544-55.