PDGF-C Protein

Platelet Derived Growth Factor C

PDGF-C Products

PDGF-C Protein, Recombinant

Molecule	Species	Description	Cat. No
PDGF-C	Human	PDGF-C/Fc Protein, Recombinant	10273-H01H
PDGF-C	Mouse	PDGF-C Protein, Recombinant	50458-M01H

  10273-H01H:  ED₅₀ = 124.5 ng / mlMeasured in a cell proliferation assay using BALB/3T3 mouse embryonic fibroblasts.

PDGF-C cDNA Clone

Molecule	Species	Description	Cat. No
PDGF-C	Human	Homo sapiens PDGF-C cDNA Clone(NM_016205.1)	HG10273-M
PDGF-C	Mouse	Mus musculus PDGF-C cDNA Clone	MG50458-M

PDGF-C Alternative Names

PDGFC, FALLOTEIN, SCDGF [Homo sapiens]

PDGF-C, Pdgfc, 1110064L01Rik, AI647969 [Mus musculus]

PDGF-C Related Areas

Cardiovascular>>Platelet>>PDGF-C

Cancer>>Growth factor & Receptor>>PDGF & Receptor>>PDGF-C

PDGF-C Related Products

Protein Products

Molecule	Species	Description //For Detailed Info. and Price------CLICK!
PDGF-D	Human	PDGF-D/Fc Protein, Recombinant
PDGFRA/CD140a	Human	PDGFRA/Fc Protein, Recombinant
PDGFRA/CD140a	Human	PDGFRA Protein, Recombinant
PDGFRA/CD140a	Human	PDGFRA Protein, Recombinant
PDGFRB/CD140b	Human	PDGFRB/CD140b Protein, Recombinant
PDGFRB/CD140b	Human	PDGFRB Protein, Recombinant

Antibody Products

Molecule	Application	Description //For Detailed Info. and Price------CLICK!
Human PDGFRA/CD140a	ELISA	Mouse Monoclonal Antibody
Human PDGFRA/CD140a	WB, ELISA	Rabbit Polyclonal Antibody
Human PDGFRA/CD140a	WB, ELISA	Rabbit Polyclonal Antibody (Antigen Affinity Purified)
Human PDGFRB/CD140b	ELISA	Mouse Monoclonal Antibody
Human PDGFRB/CD140b	WB, ELISA	Rabbit Polyclonal Antibody
Human PDGFRB/CD140b	WB, ELISA	Rabbit Polyclonal Antibody (Antigen Affinity Purified)

cDNA Clone Products

Molecule	Species	Description //For Detailed Info. and Price------CLICK!
PDGF-A	Human	Human PDGF-A cDNA Clone / ORF Clone
PDGF-A	Mouse	Mus musculus PDGF-A cDNA Clone
PDGF-A	Rat	Rat PDGF-A cDNA Clone / ORF Clone
PDGF-B	Human	Homo sapiens PDGF-B cDNA Clone(NM_002608.2)
PDGF-B	Rat	Rattus norvegicus PDGF-B cDNA Clone
PDGF-D	Human	Homo sapiens PDGF-D transcript variant 1 cDNA Clone(NM_025208.4)
PDGFRA/CD140a	Human	Homo sapiens PDGFRA cDNA Clone(NM_006206.4)
PDGFRB/CD140b	Human	Homo sapiens PDGFRB cDNA Clone(NM_002609.3)

PDGF-C Background

PDGF-C is a member of the PDGF/VEGF family of growth factors with a unique domain organization and expression pattern. Platelet-derived growth factor receptors (PDGFRs) are catalytic receptors that have intracellular tyrosine kinase activity. They have roles in the regulation of many biological processes including embryonic development, angiogenesis, cell proliferation and differentiation, and contribute to the pathophysiology of some diseases, including cancer. There are two isoforms of the PDGFR receptor; PDGFRalpha and PDGFRbeta, which can form homo- or heterodimers. The endogenous PDGFR ligands are PDGF-A, -B, -C and -D, which induce receptor dimerization and transphosphorylation at specific tyrosine residues upon binding. This activates the intracellular kinase activity, initiating intracellular signaling through the MAPK, PI 3-K and PKCgamma pathways. PDGF-C acts as a specific ligand for alpha platelet-derived growth factor receptor homodimer, and alpha and beta heterodimer. Binding of this growth factor to its affinity receptor elicits a variety of cellular responses. PDGF-C Appears to be involved in the three stages of wound healing: inflammation, proliferation and remodeling. Involved in fibrotic processes, in which transformation of interstitial fibroblasts into myofibroblasts plus collagen deposition occurs.

PDGF-C Related Studies

1. Li X, et al. (2000) PDGF-C is a new protease-activated ligand for the PDGF alpha-receptor. Nat Cell Biol. 2 (5): 302-9.
2. Ding H, et al. (2004) A specific requirement for PDGF-C in palate formation and PDGFR-alpha signaling. Nat Genet. 36 (10): 1111-6.
3. Choi SJ, et al. (2009) The PDGF-C regulatory region SNP rs28999109 decreases promoter transcriptional activity and is associated with CL/P. European Journal of Human Genetics. 17 (11): 774-84.