Anti-PDE9A Antibody

Cat: 11745-RP02
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Anti-PDE9A Antibody (Rabbit Polyclonal antibody) General Information
Product name
Anti-PDE9A Antibody
Validated applications
ELISA
Species reactivity
Reacts with: Human
Specificity
Human PDE9A
Immunogen
Recombinant Human PDE9A protein (Catalog#11745-H07E)
Preparation
Produced in rabbits immunized with purified, recombinant Human PDE9A (rh PDE9A; Catalog#11745-H07E; O76083-2; Pro 181-Lys 506). PDE9A specific IgG was purified by Human PDE9A affinity chromatography.
Source
Polyclonal Rabbit IgG
Purification
Protein A & Antigen Affinity
Formulation
0.2 μm filtered solution in PBS with 5% trehalose
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-PDE9A Antibody (Rabbit Polyclonal antibody) Validated Applications
Application Dilution Notes
ELISA 0.5-1 μg/mL  

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-PDE9A Antibody Alternative Names
Anti-HSPDE9A2 Antibody
PDE9A Background Information

High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A, also known as PDE9A, is a member of the cyclic nucleotide phosphodiesterase family and PDE9 subfamily. PDE9A is expressed in all tissues examined (testis, brain, small intestine, skeletal muscle, heart, lung, thymus, spleen, placenta, kidney, liver, pancreas, ovary and prostate) except blood. Highest levels of PDE9A is in brain, heart, kidney, spleen, prostate and colon. Isoform PDE9A12 is found in prostate. PDE9A mRNA is widely distributed throughout the rat and mouse brain, with the highest expression observed in cerebellar Purkinje cells. PDE9A is the only cGMP-specific PDE with significant expression in the forebrain, and as such is likely to play an important role in NO-cGMP signaling. PDE9A is highly conserved between species and is widely distributed throughout the rodent brain. PDE9A is probably involved in maintenance of low cGMP levels in cells and might play an important role in a variety of brain functions involving cGMP-mediated signal transduction. PDE9A hydrolyzes the second messenger cGMP, which is a key regulator of many important physiological processes. PDE9A represents a novel drug target worthy of further study.

Full Name
phosphodiesterase 9A
References
  • Andreeva, SG. et al., 2001,J Neurosci. 21 (22):9068-76.
  • van Staveren,WC. et al., 2002, J Neurocytol. 31 (8-9):729-41.
  • Almeida,CB. et al., 2008, Br J Haematol. 142 (5):836-44.
  • Kruse,L.S. et al., 2009, Brain Res. 1281 :25-34.
  • Product Description Host Clonality Application Catalog# (PDF)
    Anti-PDE9A Antibody Rabbit Polyclonal WB,ELISA 11745-T48
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