PDE4B

Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May be involved in mediating central nervous system effects of therapeutic agents ranging from antidepressants to antiasthmatic and anti-inflammatory agents.

PDE4B Related Areas

Enzyme>>Other>>PDE4B

PDE4B Alternative Names

PDE4B, RP5-876C12.1, DKFZp686F2182, DPDE4, MGC126529, PDE4B5, PDEIVB [Homo sapiens]

Pde4b, RP23-57D24.1, Dpde4, R74983, dunce [Mus musculus]

Summaries for PDE4B

Entrez Gene summary for PDE4B:

This gene is a member of the type IV, cyclic AMP (cAMP)-specific, cyclic nucleotide phosphodiesterase (PDE) family. Cyclic nucleotides are important second messengers that regulate and mediate a number of cellular responses to extracellular signals, such as hormones, light, and neurotransmitters. The cyclic nucleotide phosphodiesterases (PDEs) regulate the cellular concentrations of cyclic nucleotides and thereby play a role in signal transduction. This gene encodes a protein that specifically hydrolyzes cAMP. Altered activity of this protein has been associated with schizophrenia and bipolar affective disorder. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.

OMIM - description for PDE4B:

Cyclic nucleotides are important second messengers that regulate and mediate a number of cellular responses to extracellular signals, such as hormones, light, and neurotransmitters. Cyclic nucleotide phosphodiesterases (PDEs) regulate the cellular concentrations of cyclic nucleotides and thereby play a role in signal transduction. PDE4B is a class IV cAMP-specific PDE .

Wikipedia summary for PDE4B:

cAMP-specific 3',5'-cyclic phosphodiesterase 4B is an enzyme that in humans is encoded by the PDE4B gene. This gene is a member of the type IV, cyclic AMP (cAMP)-specific, cyclic nucleotide phosphodiesterase (PDE) family. Cyclic nucleotides are important second messengers that regulate and mediate a number of cellular responses to extracellular signals, such as hormones, light, and neurotransmitters. The cyclic nucleotide phosphodiesterases (PDEs) regulate the cellular concentrations of cyclic nucleotides and thereby play a role in signal transduction. This gene encodes a protein that specifically hydrolyzes cAMP. Altered activity of this protein has been associated with schizophrenia and bipolar affective disorder. Alternate transcriptional splice variants, encoding different isoforms, have been characterized

Human PDE4B Protein General Information

 

• Protein names: Submitted name: Phosphodiesterase 4B, cAMP-specific (Phosphodiesterase E4 dunce homolog, Drosophila)
• Sequence length: 736 AA.
• Sequence similarities: Belongs to the cyclic nucleotide phosphodiesterase family. PDE4 subfamily.
• Catalytic activity: Adenosine 3',5'-cyclic phosphate + H2O = adenosine 5'-phosphate.
• Cofactor: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions
• Enzyme regulation: Inhibited by rolipram.
• Tissue specificity: Expressed in brain, heart, lung and skeletal muscle.

General information above from UniProt

Function for PDE4B Protein

UniProtKB:

Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May be involved in mediating central nervous system effects of therapeutic agents ranging from antidepressants to antiasthmatic and anti-inflammatory agents.

Genatlas:

• cyclic nucleotide phosphodiesterase family
• PDE4B may be involved in mediating central nervous system effects of therapeutic agents ranging from antidepressants to antiasthmatic and anti-inflammatory agents
• PDE4B predomine role of PDE4B in controlling pathophysiological processes of human lung fibroblasts

Homology for human PDE4B

• homolog to Drosophila dunce gene