Anti-PDE2A Antibody (Rabbit Polyclonal antibody) General Information
Reacts with: Human
Recombinant Human PDE2A protein (Catalog#13031-H08B)
Produced in rabbits immunized with purified, recombinant Human PDE2A (rh PDE2A; Catalog#13031-H08B; O00408-1; Glu 215-His 900). PDE2A specific IgG was purified by Human PDE2A affinity chromatography.
Polyclonal Rabbit IgG
Protein A & Antigen Affinity
0.2 μm filtered solution in PBS with 5% trehalose
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-PDE2A Antibody (Rabbit Polyclonal antibody) Validated Applications
**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********
Anti-PDE2A Antibody Alternative Names
Anti-CGS-PDE Antibody;Anti-cGSPDE Antibody;Anti-PDE2A1 Antibody;Anti-PED2A4 Antibody
PDE2A Background Information
cGMP-dependent 3',5'-cyclic phosphodiesterase, also known as cyclic GMP-stimulated phosphodiesterase and PDE2A, is a peripheral membrane protein which belongs to the cyclic nucleotide phosphodiesterase family and PDE2 subfamily. Phosphodiesterases (PDEs) comprise a family of enzymes that regulate the levels of cyclic nucleotides, key second messengers that mediate a diverse array of functions. Phosphodiesterases (PDEs) modulate signaling by cyclic nucleotides in diverse processes such as cardiac contractility, platelet aggregation, lipolysis, glycogenolysis, and smooth muscle contraction. PDE2A is an evolutionarily conserved cGMP-stimulated cAMP and cGMP PDE. PDE2A contains two GAF domains. PDE2A is expressed in brain and to a lesser extent in heart, placenta, lung, skeletal muscle, kidney and pancreas. PDE2A is a cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. PDE2A is involved in the regulation of blood pressure and fluid homeostasis by the atrial natriuretic peptide (ANP), making PDE2-type enzymes important targets for drug discovery.
phosphodiesterase 2A, cGMP-stimulated
Iffland,A. et al., 2005, Biochemistry. 44 (23):8312-25 de Oliveira,S.K. et al., 2007,J Biol Chem. 282 (18):13656-63. Stephenson,D.T. et al., 2009, J Histochem Cytochem. 57 (10):933-49. Russwurm,C. et al., 2009, J Biol Chem. 284 (38):25782-90.