PD1 Protein & Antibody (PDCD1, CD279)

Programmed Cell Death 1

PD1 Protein & Antibody Products

PD1 Protein, Recombinant

Molecule	Species	Description	Cat. No
PD1/PDCD1/CD279	Human	PD1/PDCD1/Fc Protein, Recombinant	10377-H03H
PD1/PDCD1/CD279	Human	PD1/PDCD1 Protein, Recombinant	10377-H08H
PD1/PDCD1/CD279	Mouse	PD1/PDCD1 Protein, Recombinant	50124-M03H
PD1/PDCD1/CD279	Mouse	PD1/PDCD1 Protein, Recombinant	50124-M08H

  10377-H03H: Immobilized recombinant human PD-L2 at 1µg/ml (100µl/well) can bind human PD1/Fc chimera with a linear range of 7.8-1000 ng/ml. Measured by its binding ability in a functional ELISA.

  10377-H08H: Immobilized recombinant human PD1 at 10µg/ml (100µl/well) can bind human B7-H1/PD-L1/Fc chimera with a linear range of 0.02-0.4 µg/ml. Measured by its binding ability in a functional ELISA.

  50124-M03H: Immobilized recombinant mouse PD1-L1 at 1 µg/mL (100 µl/well) can bind mouse PD1 with a linear range of 6.25-400 ng/ml.Measured by its binding ability in a functional ELISA.

Molecule	Application	Description	Cat. No
Human PD1/PDCD1/CD279	WB, ELISA	PD1/PDCD1/CD279 Antibody, Rabbit Mab	10377-R002
Human PD1/PDCD1/CD279	ELISA	Rabbit Polyclonal Antibody	10377-RP03
Human PD1/PDCD1/CD279	WB, ELISA	Rabbit Polyclonal Antibody (Antigen Affinity Purified)	10377-RP04
Mouse PD1/PDCD1/CD279	WB, ELISA	Rabbit Polyclonal Antibody	50124-RP01
Mouse PD1/PDCD1/CD279	WB, ELISA	Rabbit Polyclonal Antibody(Antigen Affinity Purified)	50124-RP02

PD1 ELISA Kit

Molecule	Application	Description	Cat. No
Human PD1/PDCD1/CD279	ELISA	PD1/PDCD1/CD279 ELISA Kit	SEK10377

PD1 cDNA Clone

Molecule	Species	Description	Cat. No
PD1/PDCD1/CD279	Human	Homo sapiens PD1/PDCD1 cDNA Clone(NM_005018.2)	HG10377-M
PD1/PDCD1/CD279	Mouse	Mus musculus PD1/PDCD1 cDNA Clone	MG50124-M

PD1 Related Areas

Immunology>>Adaptive Immunity>>Costimulation & Costimulatory Molecule>>PD1/PDCD1/CD279

Immunology>>Adaptive Immunity>>T Cell>>Regulatory T Cell>>PD1/PDCD1/CD279

Immunology>>Cluster of Differentiation>>B Cell CD Antigen>>PD1/PDCD1/CD279

Immunology>>Cluster of Differentiation>>T Cell CD Antigen>>Regulatory T Cells>>PD1/PDCD1/CD279

PD1 Alternative Names

PDCD1, PD1, CD279, SLEB2, hPD-1, hPD-l [Homo sapiens]

Pdcd1, PD-1, CD279, Ly101, Pdc1 [Mus musculus]

PD1 Background

Programmed cell death 1, also known as PDCD1, is a type I transmembrane glycoprotein, and is an immunoreceptor belonging to the CD28/CTLA-4 family negatively regulates antigen receptor signaling by recruiting protein tyrosine phosphatase, SHP-2 upon interacting with either of two ligands, PD-L1 or PD-L2. PD1 inhibits the T-cell proliferation and production of related cytokines including IL-1, IL-4, IL-10 and IFN-γ by suppressing the activation and transduction of PI3K/AKT pathway. In addition, coligation of PD1 inhibits BCR-mediating signal by dephosphorylating key signal transducer. PD1 has been suggested to be involved in lymphocyte clonal selection and peripheral tolerance, and thus contributes to the prevention of autoimmune diseases. Furthermore, PD1 is shown to be a regulator of virus-specific CD8+ T cell survival in HIV infection. As a cell surface molecule, PDCD1 regulates the adaptive immune response. Engagement of PD-1 by its ligands PD-L1 or PD-L2 transduces a signal that inhibits T-cell proliferation, cytokine production, and cytolytic function.

PD1 Related Studies

1. James ES, et al. (2005) PDCD1: a tissue-specific susceptibility locus for inherited inflammatory disorders. Genes Immun. 6(5): 430-7.
2. Okazaki T, et al. (2007) PD-1 and PD-1 ligands: from discovery to clinical application. Int Immunol. 19(7): 813-24.
3. del Rio ML, et al. (2008) PD-1/PD-L1, PD-1/PD-L2, and other co-inhibitory signaling pathways in transplantation. Transpl Int. 21(11): 1015-28.
4. Riley JL.(2009) PD-1 signaling in primary T cells. Immunol Rev. 229(1): 114-25.