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PD1/PDCD1/CD279

  • PD1 / PDCD1 / CD279 Neutralizing Antibody
  • PD1 / PDCD1 / CD279 Neutralizing Antibody
  • PD1 / PDCD1 / CD279 Neutralizing Antibody
  • PD1 / PDCD1 / CD279 Neutralizing Antibody
  • PD1 / PDCD1 / CD279 Neutralizing Antibody
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Human PDCD1 Antibody Product Information
Immunogen:Recombinant Human PD1 / PDCD1 / CD279 Protein (Catalog#10377-H08H)
Clone ID:H944
Ig Type:Human IgG4
Concentration:
Endotoxin:< 0.5 EU/mg
Formulation:0.2 μm filtered solution in Histidine and Arginine buffer containing 120mM NaCl, 0.02% Tween 80, pH6.0
Preparation:This antibody was a humanized antibody obtained from a mouse immunized with the recombinant Human PD1 / PDCD1 Protein (Catalog#10377-H08H; NP_005009.2; Met 1-Gln 167) and was produced using recombinant antibody technology.
Human PDCD1 Antibody Neutralization Application Image
PD1 / PDCD1 / CD279 Neutralizing Antibody
[Click to enlarge image]
Caption:
Effect of Human PD1 H944 antibody on IFN-gamma production in the Mixed Lymphocyte Reaction (MLR). Purified CD4+ T cells were cultured with allogeneic dendritic cells, as prepared by culturing monocytes in GM-CSF and IL-4 medium for six days, in the medium containing serial concentrations of human PD1-H944-IgG4 (Catalog 10377-H944) or anti-H7N9-IgG4(isotype matched negative control antibody). Five days later, the IFNg production in the medium was evaluated. DC stands for dendritic cells.
Other PDCD1 Antibody Products
Immunochemical staining of human CD40 in human tonsil with rabbit polyclonal antibody (0.5 µg/mL, formalin-fixed paraffin embedded sections).
PD1/PDCD1/CD279 Background

Programmed cell death 1, also known as PDCD1, is a type I transmembrane glycoprotein, and is an immunoreceptor belonging to the CD28/CTLA-4 family negatively regulates antigen receptor signaling by recruiting protein tyrosine phosphatase, SHP-2 upon interacting with either of two ligands, PD-L1 or PD-L2. PD1 inhibits the T-cell proliferation and production of related cytokines including IL-1, IL-4, IL-10 and IFN-γ by suppressing the activation and transduction of PI3K/AKT pathway. In addition, coligation of PD1 inhibits BCR-mediating signal by dephosphorylating key signal transducer. PD1 has been suggested to be involved in lymphocyte clonal selection and peripheral tolerance, and thus contributes to the prevention of autoimmune diseases. Furthermore, PD1 is shown to be a regulator of virus-specific CD8+ T cell survival in HIV infection. As a cell surface molecule, PDCD1 regulates the adaptive immune response. Engagement of PD-1 by its ligands PD-L1 or PD-L2 transduces a signal that inhibits T-cell proliferation, cytokine production, and cytolytic function.

Immune Checkpoint
Immune Checkpoint Blockade: Blocking Antibodies   Immune Checkpoint Blockade: PD1 / PDCD1 / CD279 Blocking Antibodies
Immune Checkpoint Detection: Antibodies   Immune Checkpoint Detection: ELISA Antibodies   Immune Checkpoint Detection: IHC Antibodies   Immune Checkpoint Detection: WB Antibodies
Immune Checkpoint Proteins   PD1 / PDCD1 / CD279 Immune Checkpoint Proteins
PD1 / PDCD1 / CD279 Immune Checkpoint   PD1 / PDCD1 / CD279 Immune Checkpoint Antibodies
Immune Checkpoint Targets   Co-inhibitory Immune Checkpoint Targets

Immunotherapy   Cancer Immunotherapy   Targeted Therapy

Human PD1/PDCD1/CD279 References
  • James ES, et al. (2005) PDCD1: a tissue-specific susceptibility locus for inherited inflammatory disorders. Genes Immun. 6(5): 430-7.
  • Okazaki T, et al. (2007) PD-1 and PD-1 ligands: from discovery to clinical application. Int Immunol. 19(7): 813-24.
  • del Rio ML, et al. (2008) PD-1/PD-L1, PD-1/PD-L2, and other co-inhibitory signaling pathways in transplantation. Transpl Int. 21(11): 1015-28.
  • Riley JL.(2009) PD-1 signaling in primary T cells. Immunol Rev. 229(1): 114-25.
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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"