Anti-PD-1 Antibody

Cat: 10377-RP03
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All PD-1 Reagents
Anti-PD-1 Antibody (Rabbit Polyclonal antibody) General Information
Product name
Anti-PD-1 Antibody
Validated applications
ELISA
Species reactivity
Reacts with: Human
Specificity
Human PD-1
Immunogen
Recombinant Human PD1 / PDCD1 protein (Catalog#10377-H08H)
Preparation
Produced in rabbits immunized with purified, recombinant Human PD1 extracellular domain (rhPD1; Catalog#10377-H08H; Met 1-Gln 167; NP_005009.2). Total IgG was purified by Protein A affinity chromatography.
Source
Polyclonal Rabbit IgG
Purification
Protein A
Formulation
0.2 μm filtered solution in PBS
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-PD-1 Antibody (Rabbit Polyclonal antibody) Validated Applications
Application Dilution Notes
ELISA 1:1000-1:2000  

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-PD-1 Antibody Alternative Names
Anti-CD279 Antibody;Anti-hPD-1 Antibody;Anti-hPD-l Antibody;Anti-hSLE1 Antibody;Anti-PD-1 Antibody;Anti-PD1 Antibody;Anti-SLEB2 Antibody
PD-1 Background Information

Programmed cell death 1, also known as PDCD1, is a type I transmembrane glycoprotein, and is an immunoreceptor belonging to the CD28/CTLA-4 family negatively regulates antigen receptor signaling by recruiting protein tyrosine phosphatase, SHP-2 upon interacting with either of two ligands, PD-L1 or PD-L2. PD1 inhibits the T-cell proliferation and production of related cytokines including IL-1, IL-4, IL-10 and IFN-γ by suppressing the activation and transduction of PI3K/AKT pathway. In addition, coligation of PD1 inhibits BCR-mediating signal by dephosphorylating key signal transducer. PD1 has been suggested to be involved in lymphocyte clonal selection and peripheral tolerance, and thus contributes to the prevention of autoimmune diseases. Furthermore, PD1 is shown to be a regulator of virus-specific CD8+ T cell survival in HIV infection. As a cell surface molecule, PDCD1 regulates the adaptive immune response. Engagement of PD-1 by its ligands PD-L1 or PD-L2 transduces a signal that inhibits T-cell proliferation, cytokine production, and cytolytic function.

Immune Checkpoint
Immune Checkpoint Blockade: Blocking Antibodies   Immune Checkpoint Blockade: PD1 / PDCD1 / CD279 Blocking Antibodies
Immune Checkpoint Detection: Antibodies   Immune Checkpoint Detection: ELISA Antibodies   Immune Checkpoint Detection: IHC Antibodies   Immune Checkpoint Detection: WB Antibodies
Immune Checkpoint Proteins   PD1 / PDCD1 / CD279 Immune Checkpoint Proteins
PD1 / PDCD1 / CD279 Immune Checkpoint   PD1 / PDCD1 / CD279 Immune Checkpoint Antibodies
Immune Checkpoint Targets   Co-inhibitory Immune Checkpoint Targets

Immunotherapy   Cancer Immunotherapy   Targeted Therapy

Full Name
programmed cell death 1
References
  • James ES, et al. (2005) PDCD1: a tissue-specific susceptibility locus for inherited inflammatory disorders. Genes Immun. 6(5): 430-7.
  • Okazaki T, et al. (2007) PD-1 and PD-1 ligands: from discovery to clinical application. Int Immunol. 19(7): 813-24.
  • del Rio ML, et al. (2008) PD-1/PD-L1, PD-1/PD-L2, and other co-inhibitory signaling pathways in transplantation. Transpl Int. 21(11): 1015-28.
  • Riley JL.(2009) PD-1 signaling in primary T cells. Immunol Rev. 229(1): 114-25.
  • Product Description Host Clonality Application Catalog# (PDF)
    Anti-PD-1 Antibody Rabbit Polyclonal ELISA,IP 70109-T20
    Anti-PD-1 Antibody Mouse Monoclonal IHC-P 90305-MM09
    Anti-PD-1 Antibody Rabbit Monoclonal ELISA 70109-R039
    Anti-PD-1 Antibody Rabbit Polyclonal WB,IP 108583-T36
    Anti-PD-1 Antibody Rabbit Polyclonal ELISA,IHC-P 90305-T24
    Anti-PD-1 Antibody Rabbit Monoclonal ELISA 50124-R010
    Anti-PD-1 Antibody Rabbit Polyclonal ELISA,IHC-P 50124-RP02
    Anti-PD-1 Antibody Rabbit Polyclonal ELISA 50124-RP01
    Anti-PD-1 Antibody Rabbit Polyclonal ELISA 50124-T16
    Anti-PD-1 Antibody Rabbit Monoclonal ELISA,IHC-P 10377-RD67
    Anti-PD-1 Antibody Mouse Monoclonal ELISA,ELISA(Cap) 10377-MM07
    Anti-PD-1 Antibody (FITC) Mouse Monoclonal FCM 10377-MA04-F
    Anti-PD-1 Antibody Mouse Monoclonal ELISA,IHC-P 10377-MF07
    Anti-PD-1 Antibody Mouse Monoclonal ELISA 10377-MM18
    Anti-PD-1 Antibody Rabbit Polyclonal ELISA 10377-RP04
    Anti-PD-1 Antibody (PE) Mouse Monoclonal FCM 10377-MA04-P
    Anti-PD-1 Antibody Mouse Monoclonal ELISA 10377-MF05
    Anti-PD-1 Antibody Rabbit Polyclonal WB,ELISA 10377-T48
    Anti-PD-1 Antibody (PE) Mouse Monoclonal FCM 10377-M140-P
    Anti-PD-1 Antibody Mouse Monoclonal FCM 10377-M140
    Anti-PD-1 Antibody Mouse Monoclonal IHC-P 10377-MM23
    Anti-PD-1 Antibody Mouse Monoclonal ELISA 10377-MM03
    Anti-PD-1 Antibody Mouse Monoclonal FCM 10377-MA04
    PD1 / PDCD1 / CD279 Neutralizing Antibody Neutralization 10377-HN94
    Anti-PD-1 Antibody Rabbit Monoclonal ELISA 10377-R002
    PD1 / PDCD1 / CD279 Blocking Antibody Mouse Monoclonal Neutralization 10377-mhT28
    PD1 / PDCD1 / CD279 Neutralizing Antibody Neutralization 10377-HF06
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