Anti-PD-L1 Antibody

Cat: 10084-R015
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All PD-L1 Reagents
Anti-PD-L1 Antibody (Rabbit Monoclonal antibody) General Information
Product name
Anti-PD-L1 Antibody
Validated applications
ELISA,IHC-P
Species reactivity
Reacts with: Human
Specificity
Human PD-L1
No cross-reactivity in ELISA with Human B7-1 Human B7-2 Mouse B7-H1 Non-blocking This B7-H1/PD-L1 antibody can not block the binding of recombinant PD1 (10377-H03H) to its recombinant ligand B7-H1/PD-L1 (10084-H02H).
Immunogen
Recombinant Human PD-L1 / B7-H1 / CD274 protein (Catalog#10084-H08H)
Preparation
This antibody was obtained from a rabbit immunized with purified, recombinant Human PD-L1 / B7-H1 / CD274 (rh PD-L1 / B7-H1 / CD274; Catalog#10084-H08H; NP_054862.1; Met 1-Thr 239).
Source
Monoclonal Rabbit IgG Clone #015
Purification
Protein A
Formulation
0.2 μm filtered solution in PBS
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-PD-L1 Antibody (Rabbit Monoclonal antibody) Validated Applications
Application Dilution Notes
ELISA 1:5000-1:10000  
IHC-P 1:100-1:500  

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-PD-L1 Antibody (Rabbit Monoclonal antibody) Images
Human PD-L1/B7-H1/CD274 Immunohistochemistry(IHC) 4660
Immunochemical staining of human B7H1 in human placenta with rabbit monoclonal antibody (1:200, formalin-fixed paraffin embedded sections). Positive staining was localized to trophoblast.
Anti-PD-L1 Antibody Alternative Names
Anti-B7-H Antibody;Anti-B7-H1 Antibody;Anti-B7H1 Antibody;Anti-PD-L1 Antibody;Anti-PDCD1L1 Antibody;Anti-PDCD1LG1 Antibody;Anti-PDL1 Antibody
PD-L1 Background Information

Programmed death-1 ligand-1 (PD-L1, CD274, B7-H1) has been identified as the ligand for the immunoinhibitory receptor programmed death-1(PD1/PDCD1) and has been demonstrated to play a role in the regulation of immune responses and peripheral tolerance. PD-L1/B7-H1 is a member of the growing B7 family of immune molecules and this protein contains one V-like and one C-like Ig domain within the extracellular domain, and together with PD-L2, are two ligands for PD1 which belongs to the CD28/CTLA4 family expressed on activated lymphoid cells. By binding to PD1 on activated T-cells and B-cells, PD-L1 may inhibit ongoing T-cell responses by inducing apoptosis and arresting cell-cycle progression. Accordingly, it leads to growth of immunogenic tumor growth by increasing apoptosis of antigen specific T cells and may contribute to immune evasion by cancers. PD-L1 thus is regarded as promising therapeutic target for human autoimmune disease and malignant cancers.

Immune Checkpoint
Immune Checkpoint Blockade: Blocking Antibodies   Immune Checkpoint Blockade: PD-L1 / B7-H1 / CD274 Blocking Antibodies
Immune Checkpoint Detection: Antibodies   Immune Checkpoint Detection: ELISA Antibodies   Immune Checkpoint Detection: IHC Antibodies   Immune Checkpoint Detection: ICC Antibodies   Immune Checkpoint Detection: FCM Antibodies   Immune Checkpoint Detection: WB Antibodies
Immune Checkpoint Proteins   PD-L1 / B7-H1 / CD274 Immune Checkpoint Proteins
Immune Checkpoint Targets   Co-inhibitory Immune Checkpoint Targets

Immunotherapy   Cancer Immunotherapy   Targeted Therapy

Full Name
CD274 molecule
References
  • Iwai Y, et al. (2002) Involvement of PD-L1 on tumor cells in the escape from host immune system and tumor immunotherapy by PD-L1 blockade. Proc Natl Acad Sci U S A. 99(19): 12293-7.
  • Ghebeh H, et al. (2006) The B7-H1 (PD-L1) T lymphocyte-inhibitory molecule is expressed in breast cancer patients with infiltrating ductal carcinoma: correlation with important high-risk prognostic factors. Neoplasia. 8(3): 190-8.
  • Salih HR, et al. (2006) The role of leukemia-derived B7-H1 (PD-L1) in tumor-T-cell interactions in humans. Exp Hematol. 34(7): 888-94.
  • Wilcox RA, et al. (2009) B7-H1 (PD-L1, CD274) suppresses host immunity in T-cell lymphoproliferative disorders. Blood. 114(10): 2149-58.
  • Ruggiero A, et al. (2009) Crystal structure of PD-L1, a ribosome inactivating protein from Phytolacca dioica L. leaves with the property to induce DNA cleavage. Biopolymers. 91(12): 1135-42.
  • Product Description Host Clonality Application Catalog# (PDF)
    Anti-PD-L1 Antibody Rabbit Polyclonal WB,ELISA 90251-T48
    Anti-PD-L1 Antibody Rabbit Polyclonal ELISA,IP 90251-T20
    Anti-PD-L1 Antibody Rabbit Polyclonal ELISA 90251-T16
    Anti-PD-L1 Antibody (PE) Rabbit Monoclonal FCM 50010-R485-P
    Anti-PD-L1 Antibody Rabbit Polyclonal WB 50010-T32
    Anti-PD-L1 Antibody Rabbit Monoclonal ELISA 50010-R678
    Anti-PD-L1 Antibody Rabbit Monoclonal FCM,ICC/IF,IF 50010-R485
    Anti-PD-L1 Antibody Rabbit Monoclonal FCM 50010-R401
    Anti-PD-L1 Antibody Rabbit Polyclonal ELISA 50010-RP01
    Anti-PD-L1 Antibody (APC) Rabbit Monoclonal FCM 50010-R485-A
    Anti-PD-L1 Antibody Rabbit Polyclonal ELISA 50010-RP02
    Anti-PD-L1 Antibody (APC) Rabbit Monoclonal FCM 10084-R312-A
    Anti-PD-L1 Antibody Rabbit Polyclonal ELISA 10084-RP02
    Anti-PD-L1 Antibody Rabbit Polyclonal ELISA 10084-RP01
    PD-L1 / B7-H1 / CD274 Blocking Antibody Rabbit Monoclonal Neutralization 10084-R639
    Anti-PD-L1 Antibody Mouse Monoclonal WB,IP 10084-MM33
    Anti-PD-L1 Antibody (FITC) Rabbit Monoclonal FCM 10084-R312-F
    Anti-PD-L1 Antibody Rabbit Monoclonal FCM 10084-R312
    Anti-PD-L1 Antibody Rabbit Monoclonal ELISA 10084-R001
    Anti-PD-L1 Antibody (APC) Rabbit Monoclonal FCM 10084-R611-A
    Anti-PD-L1 Antibody Rabbit Monoclonal FCM 10084-R611
    Anti-PD-L1 Antibody Mouse Monoclonal ELISA 10084-MM31
    Anti-PD-L1 Antibody (PE) Mouse Monoclonal FCM 10084-MM36-P
    Anti-PD-L1 Antibody (APC) Mouse Monoclonal FCM 10084-MM36-A
    Anti-PD-L1 Antibody Mouse Monoclonal IHC-P 10084-MB55
    Anti-PD-L1 Antibody Mouse Monoclonal ELISA 10084-MM02
    Anti-PD-L1 Antibody (FITC) Rabbit Monoclonal FCM 10084-R611-F
    Anti-PD-L1 Antibody (PE) Rabbit Monoclonal FCM 10084-R611-P
    Anti-PD-L1 Antibody Mouse Monoclonal ELISA 10084-MM37
    Anti-PD-L1 Antibody Mouse Monoclonal FCM 10084-MM36
    Anti-PD-L1 Antibody Rabbit Polyclonal ELISA,IHC-P 10084-T24
    Anti-PD-L1 Antibody Rabbit Polyclonal ELISA 10084-T16
    Anti-PD-L1 Antibody (FITC) Mouse Monoclonal FCM 10084-MM36-F
    Anti-PD-L1 Antibody (PE) Rabbit Monoclonal FCM 10084-R312-P
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