Catalytic activity: Thymidine + phosphate = thymine + 2-deoxy- alpha-D-ribose 1-phosphate.
Subunit structure: Homodimer.
Involvement in disease: Mitochondrial DNA depletion syndrome 1 (MTDPS1) [MIM:603041]: A multisystem disease associated with mitochondrial dysfunction. It is clinically characterized by onset between the second and fifth decades of life, ptosis, progressive external ophthalmoplegia, gastrointestinal dysmotility (often pseudoobstruction), diffuse leukoencephalopathy, cachexia, peripheral neuropathy, and myopathy. Note=The disease is caused by mutations affecting the gene represented in this entry.
Sequence similarity: Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family.
General information above from UniProt