PCSK9 Protein & Antibody

Proprotein Convertase Subtilisin/Kexin type 9

PCSK9 Alternative Names

PCSK9, PSEC0052, FH3, HCHOLA3, LDLCQ1, NARC-1, NARC1, PC9 [Homo sapiens]

Pcsk9, RP23-159J7.1, AI415265, AI747682, FH3, HCHOLA3, MGC47409, Narc1, PC9 [Mus musculus]

Pcsk9, NARC-1, Narc1, PC9 [Rattus norvegicus]

Pcsk9, PC9 [Macaca mulatta]

PCSK9 Protein and Antibody

Sino Biological offers a comprehensive set of research tools (proteins, antibodies) for proprotein convertase subtilisin/kexin type 9 (PCSK9) related research. Our antibody products include mouse monoclonal and rabbit polyclonal antibodies for application such as ELISA, Western Blotting, IHC, etc. All of our antibodies were generated with recombinant full length protein as immunogen, which ensures better binding affinity and specificity to the native protein.

PCSK9 Protein, Recombinant

Molecule	Species	Description //For Detailed Info. and Price------CLICK!	Cat. No
PCSK9	Human	PCSK9 protein, Recombinant	10594-H08H
PCSK9	Mouse	PCSK9 protein, Recombinant	50251-M08H
PCSK9	Rat	PCSK9 protein, Recombinant	80005-R08H
PCSK9	Rhesus	PCSK9 protein, Recombinant	11054-K08H

  10594-H08H: Immobilized recombinant human PCSK9 at 10 µg/mL (100 µl/well) can bind biotinylated human LDLR. The EC₅₀ of biotinylated human LDLR is 0.61 µg/mL. Measure by its ability to bind with human LDLR in a functional ELISA.

  50251-M08H:  Immobilized mouse PCSK9 at 10 μg/mL (100 μl/well) can bind biotinylated recombinant human LDLR. The EC₅₀ of biotinylated human LDLR is 0.12 μg/mL. Measured by its binding ability in a functional ELISA.

PCSK9 Antibody

Molecule	Application	Description //For Detailed Info. and Price------CLICK!	Cat. No
Human PCSK9	WB, ELISA	Mouse Monoclonal Antibody	10594-MM01
Human PCSK9	WB	Rabbit Monoclonal Antibody	10594-RM03
Human PCSK9	WB, ELISA	Rabbit Polyclonal Antibody	10594-RP02
Human PCSK9	WB, ELISA	Rabbit Polyclonal Antibody (Antigen Affinity Purified)	10594-RP04
Mouse PCSK9	WB, ELISA	PCSK9 Antibody, Rabbit PAb	50251-RP01
Mouse PCSK9	WB, ELISA	PCSK9 Antibody, Rabbit PAb (Antigen Affinity Purified)	50251-RP02
Mouse PCSK9	WB, ELISA	PCSK9 Antibody, Rabbit MAb	50251-R106
Rat PCSK9	WB, ELISA	PCSK9 Antibody, Rabbit PAb	80005-RP01
Rat PCSK9	WB, ELISA	PCSK9 Antibody, Rabbit PAb (Antigen Affinity Purified)	80005-RP02

PCSK9 Related Areas

Enzyme>>Protease & Regulator>>Serine Protease & Regulator>>PCSK9

Enzyme>>Lipid Metabolism Enzymes>>PCSK9

Cardiovascular>>Lipid Metabolism>>Lipid Metabolism Enzymes>>PCSK9

PCSK9 Related Products

LDL Receptor Protein

Molecule	Species	Description //For Detailed Info. and Price------CLICK!
LDL Receptor	Human	LDL Receptor Protein, Recombinant
LDL Receptor	Mouse	LDL Receptor Protein, Recombinant

LDL Receptor Antibody

Molecule	Application	Description //For Detailed Info. and Price------CLICK!
Human LDL Receptor	WB, ELISA	LDL Receptor Antibody, Mouse MAb
Human LDL Receptor	WB, ELISA	LDL Receptor Antibody, Rabbit Mab
Human LDL Receptor	WB, ELISA	LDL Receptor Antibody, Rabbit Mab
Human LDL Receptor	WB, ELISA	Rabbit Polyclonal Antibody
Human LDL Receptor	WB, ELISA	Rabbit Polyclonal Antibody (Antigen Affinity Purified)
Mouse LDL Receptor	WB, ELISA	LDL Receptor Antibody, Rabbit MAb
Mouse LDL Receptor	WB, ELISA	LDL Receptor Antibody, Rabbit PAb
Mouse LDL Receptor	WB, ELISA	LDL Receptor Antibody, Rabbit PAb (Antigen Affinity Purified)

LDL Receptor cDNA Clone

Molecule	Species	Description //For Detailed Info. and Price------CLICK!
LDL Receptor	Human	Homo sapiens LDL Receptor/LDLR cDNA Clone(NM_000527.3)
LDL Receptor	Mouse	Mus musculus LDL Receptor/LDLR cDNA Clone

PCSK9 Background

Proprotein convertase subtilisin/kexin type 9 (PCSK9), also known as NARC1 (neural apoptosis regulated convertase), which is a newly identified human secretory subtilase belonging to the proteinase K subfamily of the secretory subtilase family. PCSK9 protein is an enzyme which in humans is encoded by the PCSK9 gene with orthologs found across many species. It is expressed in neuroepithelioma, colon carcinoma, hepatic and pancreatic cell lines, and in Schwann cells. PCSK9 protein is highly expressed in the liver and regulates low density lipoprotein receptor (LDLR) protein levels. Inhibition of PCSK9 protein function is currently being explored as a means of lowering cholesterol levels. Thereby, PCSK9 protein is regarded as a new strategy to treat hypercholesterolemia. PCSK9 protein contributes to cholesterol homeostasis and may have a role in the differentiation of cortical neurons.

References

1. Horton JD, et al. (2007) Molecular biology of PCSK9: its role in LDL metabolism. Trends Biochem Sci. 32 (2) :71-7.
2. Duff CJ, et al. (2009) Antibody-mediated disruption of the interaction between PCSK9 and the low-density lipoprotein receptor. Biochem J. 419(3): 577-84.